CAJ | 학술논문

目的：探讨脑卒中血清低氧诱导因子－1α（HIF－1α）与认知障碍发生的相关性。方法新发缺血性脑卒中患者入院后24 h内进行血清 HIF－1α的检测；卒中后2周行认知评估；Pearson's相关系数及Logistic回归分析评估 HIF－1α与认知障碍的相关性。结果137例脑卒中患者依据认知障碍程度分成无认知障碍（NCI）组64例、血管性轻度认知障碍（VCIND）组37例和血管性痴呆（VaD）组36例。结果发现VaD患者血清HIF－1α水平相较于 NCI组显著升高，而VCIND和NCI组患者无明显差异。相关分析结果则表明血清 HIF－1α水平与认知障碍明显相关。结论 HIF －1α血清水平的变化可能在早期诊断卒中后认知障碍方面具有重要临床意义。
목적：탐토뇌졸중혈청저양유도인자－1α（HIF－1α）여인지장애발생적상관성。방법신발결혈성뇌졸중환자입원후24 h내진행혈청 HIF－1α적검측；졸중후2주행인지평고；Pearson's상관계수급Logistic회귀분석평고 HIF－1α여인지장애적상관성。결과137례뇌졸중환자의거인지장애정도분성무인지장애（NCI）조64례、혈관성경도인지장애（VCIND）조37례화혈관성치태（VaD）조36례。결과발현VaD환자혈청HIF－1α수평상교우 NCI조현저승고，이VCIND화NCI조환자무명현차이。상관분석결과칙표명혈청 HIF－1α수평여인지장애명현상관。결론 HIF －1α혈청수평적변화가능재조기진단졸중후인지장애방면구유중요림상의의。
Objective To study the correlation between serum HIF-1αlevel and cognitive impair‐ment after stroke .Methods First-ever stroke patients were recruited and detected serum HIF-1αlevel in 24 hours after admission .Cognitive status was evaluated by a set of cognitive assessments 2 weeks af‐ter stroke .Relationships between the serum HIF -1α level and cognitive impairment after stroke were calculated by Pearson's correlation coefficient and logistic regression analysis .Results 137 cases in ac‐cordance with the degree of cognitive disorders in stroke patients were divided into the following groups:64 Non-cognitive impairment (NCI) ,37 vascular cognitive impairment with no dementia (VCIND) and 36 vascular dementia (VaD) .The findings indicated that the serum HIF-1αlevel of patients with VaD was higher than NCI group ,However ,the serum HIF-1αlevel of NCI group and VCIND group had no difference .Correlational analysis determined that HIF-1αhad significant relationships with the results of cognitive assessments .Conclusions Serum HIF -1αchanges may has important clinical significance in early diagnosis of cognitive impairment after stroke .