CAJ | 학술논문

目的：研究一种全新合成的抗抑郁药物AJS的自微乳化制剂（ AJS-SMEDDS）的理化性质和体外释药行为。方法考察AJS-SMEDDS制剂的黏度、zeta电位和粒度，研究其流变学性质及电学性质；采用总体液平衡反向透析法测定其体外释药性能；并考察了其稳定性。结果 AJS-SMEDDS制剂为塑性流体，在分散介质中所形成的乳滴zeta电位为-2.76 mV，粒径为（26.08±1.68）nm，制剂质量稳定，低温不影响其性能。结论 AJS -SMEDDS制剂质量稳定，适合工业生产。
목적：연구일충전신합성적항억욱약물AJS적자미유화제제（ AJS-SMEDDS）적이화성질화체외석약행위。방법고찰AJS-SMEDDS제제적점도、zeta전위화립도，연구기류변학성질급전학성질；채용총체액평형반향투석법측정기체외석약성능；병고찰료기은정성。결과 AJS-SMEDDS제제위소성류체，재분산개질중소형성적유적zeta전위위-2.76 mV，립경위（26.08±1.68）nm，제제질량은정，저온불영향기성능。결론 AJS -SMEDDS제제질량은정，괄합공업생산。
Objective To study the physicochemical properties and in vitro release of a self-microemulsifying drug delivery system( SMEDDS)of AJS,the code name of an untitled novel medicative compound. Methods To study the rheo-logical properties and electrical properties of AJS-SMEDDS by examining its viscosity,zeta potential and particle size. The in vitro release of AJS-SMEDDS was examined by the bulk-equilibrium reverse dialysis bag technique. The stability of AJS-SMEDDS was also examined. Results AJS-SMEDDS was a plastic fluid with a zeta potential of -2. 76 mV and a particle size of(26. 08 ± 1. 68)nm. The quality of AJS-SMEDDS was stable during storing period in room temperature as well as low temperature. Conclusion AJS-SMEDDS was suitable for industrial production with a stable quality.