CAJ | 학술논문

对于复杂性胃肠间质瘤（GIST），目前除零星描述或个案报道外，少见系统报道，且未有明确的定义。由于此类GIST其侵袭性和恶性程度高，细胞异形明显，围绕血管密集排列呈古钱币样，且具有肿瘤性坏死、肌层浸润、黏膜层或浆膜层浸润、脉管和神经浸润等特性，总体预后不良。故提倡早诊断、早治疗。外科手术结合酪氨酸激酶抑制剂靶向药物是治疗复杂性GIST的有效方法。本文从疾病定义、临床特征、手术和药物治疗以及预后等方面对复杂性GIST进行讨论，从而为临床医生提供相关的理论依据和临床经验。
대우복잡성위장간질류（GIST），목전제령성묘술혹개안보도외，소견계통보도，차미유명학적정의。유우차류GIST기침습성화악성정도고，세포이형명현，위요혈관밀집배렬정고전폐양，차구유종류성배사、기층침윤、점막층혹장막층침윤、맥관화신경침윤등특성，총체예후불량。고제창조진단、조치료。외과수술결합락안산격매억제제파향약물시치료복잡성GIST적유효방법。본문종질병정의、림상특정、수술화약물치료이급예후등방면대복잡성GIST진행토론，종이위림상의생제공상관적이론의거화림상경험。
Tyrosine kinase inhibitor (TKI) combined with surgical treatment is the optimal strategy for gastrointestinal stromal tumors (GIST). However, there is no systemic report about the complicated GIST (recurrence or metastasis, peritoneal dissemination, combined resection of multiple organs), except the cases review and experimental studies. Tyrosine kinase inhibitor combined with surgery may increase the overall survival of complicated GIST. This article will describe the definition, clinical features, surgical and drug therapy, and prognosis, in order to provide reliable theoretical basis and experience for clinical doctors , prolong patient survival and improve the quality of survival.