CAJ | 학술논문

本文以期通过文献复习和我院点滴经验总结，提高十二指肠胃肠间质瘤（GIST）的临床诊治能力。十二指肠GIST并非鲜见，但其位置特殊，明确术前病理诊断和实施恰当治疗仍面临挑战。在相同病理条件下十二指肠 GIST 较胃更具有恶性风险，需要进行伊马替尼治疗者术前要经超声内镜引导下细针穿刺获得病理学诊断，选择治疗策略的基本原则是在保证切缘阴性条件下进行R0切除，尽量保护脏器功能、避免联合脏器切除，对可行病例提倡做限制性切除，其与扩大手术具有相同的肿瘤学结果。
본문이기통과문헌복습화아원점적경험총결，제고십이지장위장간질류（GIST）적림상진치능력。십이지장GIST병비선견，단기위치특수，명학술전병리진단화실시흡당치료잉면림도전。재상동병리조건하십이지장 GIST 교위경구유악성풍험，수요진행이마체니치료자술전요경초성내경인도하세침천자획득병이학진단，선택치료책략적기본원칙시재보증절연음성조건하진행R0절제，진량보호장기공능、피면연합장기절제，대가행병례제창주한제성절제，기여확대수술구유상동적종류학결과。
In order to promote clinical capability on duodenal gastrointestinal stromal tumor (GIST), literature review and experience summary were documented in this paper. Duodenal GIST is not rare in clinical practice. With the similar pathologic conditions, GIST in duodenum present a higher malignant risk than that in stomach. The cases who would receive imatinib mesylate as preoperative therapy require a precise preoperative diagnosis obtained by endoscopic ultrasound and fine needle aspiration cytology. Therapeutic strategy should be based on surgical R0 resection with clear margins, preserving pancreatic function and avoiding adjacent organs resection when possible. Limited resection is appropriate and results in similar oncological outcome compared with extensive procedure in suitable cases.