中华核医学与分子影像杂志
中華覈醫學與分子影像雜誌
중화핵의학여분자영상잡지
Chinese Journal of Nuclear Medicine and Molecular Imaging
2015年
1期
41-43
,共3页
血管瘤%婴儿%近距离放射疗法%锶放射性同位素%钇放射性同位素%超声检查
血管瘤%嬰兒%近距離放射療法%鍶放射性同位素%釔放射性同位素%超聲檢查
혈관류%영인%근거리방사요법%송방사성동위소%을방사성동위소%초성검사
Hemangioma%Infant%Brachytherapy%Strontium radioisotopes%Yttrium radioisotopes%Ultrasonography
目的 探讨浅表超声评价90Sr-90Y敷贴治疗血管瘤疗效的价值.方法 回顾性分析经临床确诊的单纯性血管瘤患儿94例,其中男37例,女57例,年龄1～12(平均4.5)个月.对94例患儿进行90Sr-90Y敷贴治疗,分别在治疗前1d、治疗10 d后及治疗后3个月用浅表超声测量血管瘤的瘤体厚度及皮下范围,采用配对t检验以及x2检验进行前后对比分析.以治疗前瘤体厚度绘制ROC曲线,并计算1个疗程可治愈的瘤体厚度.结果 94例患儿中,62例治愈,29例好转,3例无效.治疗前超声下瘤体厚度为(0.38±0.28) cm,治疗3个月后的瘤体厚度为(0.16±0.35) cm,差异有统计学意义(t=7.377,P＜0.05).90Sr-90Y治疗效果不受性别影响.从血管瘤分布部位看,头颈部38例,治愈20例;胸腹部33例,治愈22例;四肢23例,治愈20例.头颈部与四肢的疗效比较差异有统计学意义(x2=7.478,P＜0.05),其余部位比较差异无统计学意义.以瘤体皮下厚度评价90Sr-90Y敷贴治疗血管瘤3个月后疗效的ROC曲线下面积为0.93,治疗前瘤体皮下厚度0.32 cm为治愈界值,灵敏度为93.8％,特异性为85.5％.结论 90Sr-90Y敷贴治疗对全身多部位的小儿单纯性血管瘤均有效,尤其是对四肢及躯干部位的血管瘤效果更好,且对于瘤体厚度小于0.32 cm的血管瘤可一次性治愈,值得临床推广应用.
目的 探討淺錶超聲評價90Sr-90Y敷貼治療血管瘤療效的價值.方法 迴顧性分析經臨床確診的單純性血管瘤患兒94例,其中男37例,女57例,年齡1～12(平均4.5)箇月.對94例患兒進行90Sr-90Y敷貼治療,分彆在治療前1d、治療10 d後及治療後3箇月用淺錶超聲測量血管瘤的瘤體厚度及皮下範圍,採用配對t檢驗以及x2檢驗進行前後對比分析.以治療前瘤體厚度繪製ROC麯線,併計算1箇療程可治愈的瘤體厚度.結果 94例患兒中,62例治愈,29例好轉,3例無效.治療前超聲下瘤體厚度為(0.38±0.28) cm,治療3箇月後的瘤體厚度為(0.16±0.35) cm,差異有統計學意義(t=7.377,P＜0.05).90Sr-90Y治療效果不受性彆影響.從血管瘤分佈部位看,頭頸部38例,治愈20例;胸腹部33例,治愈22例;四肢23例,治愈20例.頭頸部與四肢的療效比較差異有統計學意義(x2=7.478,P＜0.05),其餘部位比較差異無統計學意義.以瘤體皮下厚度評價90Sr-90Y敷貼治療血管瘤3箇月後療效的ROC麯線下麵積為0.93,治療前瘤體皮下厚度0.32 cm為治愈界值,靈敏度為93.8％,特異性為85.5％.結論 90Sr-90Y敷貼治療對全身多部位的小兒單純性血管瘤均有效,尤其是對四肢及軀榦部位的血管瘤效果更好,且對于瘤體厚度小于0.32 cm的血管瘤可一次性治愈,值得臨床推廣應用.
목적 탐토천표초성평개90Sr-90Y부첩치료혈관류료효적개치.방법 회고성분석경림상학진적단순성혈관류환인94례,기중남37례,녀57례,년령1～12(평균4.5)개월.대94례환인진행90Sr-90Y부첩치료,분별재치료전1d、치료10 d후급치료후3개월용천표초성측량혈관류적류체후도급피하범위,채용배대t검험이급x2검험진행전후대비분석.이치료전류체후도회제ROC곡선,병계산1개료정가치유적류체후도.결과 94례환인중,62례치유,29례호전,3례무효.치료전초성하류체후도위(0.38±0.28) cm,치료3개월후적류체후도위(0.16±0.35) cm,차이유통계학의의(t=7.377,P＜0.05).90Sr-90Y치료효과불수성별영향.종혈관류분포부위간,두경부38례,치유20례;흉복부33례,치유22례;사지23례,치유20례.두경부여사지적료효비교차이유통계학의의(x2=7.478,P＜0.05),기여부위비교차이무통계학의의.이류체피하후도평개90Sr-90Y부첩치료혈관류3개월후료효적ROC곡선하면적위0.93,치료전류체피하후도0.32 cm위치유계치,령민도위93.8％,특이성위85.5％.결론 90Sr-90Y부첩치료대전신다부위적소인단순성혈관류균유효,우기시대사지급구간부위적혈관류효과경호,차대우류체후도소우0.32 cm적혈관류가일차성치유,치득림상추엄응용.
Objective To evaluate the efficacy of 90Sr-90Y applicator treatment for hemangioma by superficial ultrasound.Methods A total of 94 infants with hemangioma were retrospectively analyzed,including 37 males and 57 females (age range:1-12 months,mean =4.5 months).Thickness of hemangioma was measured by superficial ultrasound on the day before 90Sr-90Y applicator treatment,10 d and 3 months after treatment.Paired t test and x2 test were used to analyze data.ROC curve was analyzed to determine the tumor thickness which could be cured by one-cycle of treatment.Results Sixty-two cases were cured,29 cases had partial response and 3 cases had treatment failure.Thickness of hemangioma was (0.38 ±0.28)cm before treatment and (0.16±0.35) cm 3 months post-treatment and the difference was statistically significant (t=7.377,P＜0.05).The treatment effect of 90Sr-90Y applicator was not influenced by gender.According to the site of hemangioma,the curative rates were 20/38 in head & neck,22/33 in chest,20/23 in limbs.Only the difference between the curative rates in head & neck and limbs was statistically significant (x2 =7.478,P＜0.05).The treatment effect of 90Sr-90Y applicator was evaluated by the thickness of hemangioma under the skin at 3 months post-treatment and the area under the ROC was 0.93.The threshold of the thickness of hemangioma which could be cured by one-cycle of treatment was 0.32 cm with the sensitivity of 93.8％ and specificity of 85.5％.Conclusions The 90Sr-90Y applicator had a good treatment effect on pure hemangioma in infants,especially for those located in limbs and torso.The lesion with thickness less than 0.32 cm had a higher chance to be cured by one-cycle of treatment.
