CAJ | 학술논문

目的：：研究苏木醇提取物对类风湿性关节炎( RA)的治疗作用。方法：构建大鼠弗氏佐剂关节炎模型( AA)，以苏木作为实验治疗组，雷公藤作为阳性对照治疗组，并且构建模型组和空白组进行比较分析，通过灌胃的形式予以给药，分别在治疗前和治疗后2周和4周检测大鼠足趾肿胀指数和放射学指数(RI)。结果：与模型组比较，苏木组的足趾肿胀指数明显下降(P<0.05)，其数值与雷公藤组效果差异无统计学意义(P>0.05)。苏木组和雷公藤组的放射学指数(RI)与模型组差异无统计学意义(P>0.05)。结论：苏木醇提取物可以减轻弗氏佐剂关节炎大鼠的足趾肿胀，但不能明显改善其骨质破坏程度。
목적：：연구소목순제취물대류풍습성관절염( RA)적치료작용。방법：구건대서불씨좌제관절염모형( AA)，이소목작위실험치료조，뢰공등작위양성대조치료조，병차구건모형조화공백조진행비교분석，통과관위적형식여이급약，분별재치료전화치료후2주화4주검측대서족지종창지수화방사학지수(RI)。결과：여모형조비교，소목조적족지종창지수명현하강(P<0.05)，기수치여뢰공등조효과차이무통계학의의(P>0.05)。소목조화뢰공등조적방사학지수(RI)여모형조차이무통계학의의(P>0.05)。결론：소목순제취물가이감경불씨좌제관절염대서적족지종창，단불능명현개선기골질파배정도。
Objective:To investigate the effects of ethanol extract of Caesalpinia sappan L. on rheumatoid arthritis ( RA) in rats. Methods:Freund’ s adjuvant arthritis ( AA) model was established in rats. The rats were assigned to four groups, including a blank control group, a model group, a group treated with ethanol extract of Caesalpinia sappan L. ( experimental treatment group) and another with Tripterygium Wilfordii ( active control group). The treatments were given by gavage. The toe swelling index and radiology index (RI) in rats at baseline and at weeks 2 and 4 after treatment were measured, respectively. Results:The toe swelling index in the Caesalpinia sappan L. treated group decreased significantly compared with the model group ( P<0.05) , and was not statistically different compared with the Tripterygium wilfordii treated group ( P>0. 05 ) . There was no statistically significant difference in RI between the treatment groups on Caesalpinia sappan L. or Tripterygium wilfordii and the model group ( P>0.05) . Conclusion:The ethanol extract of Caesalpinia sappan L. can relieve toe swelling in rats with Freund’ s AA, but can not significantly improve the severity of bone destruction.