当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2015年
12期
5-6
,共2页
冠心病%心力衰竭%胰岛素样生长因子-I
冠心病%心力衰竭%胰島素樣生長因子-I
관심병%심력쇠갈%이도소양생장인자-I
Coronary Disease%Heart Failure%Insulin-Like Growth Factor-I
目的：探讨冠心病(congenital heart disease,CHD)心力衰竭患者血清中骨保护素(osteoprotegerin，OPG)和胰岛素样生长因子(insulin-like growth factor-I，IGF-I)的水平变化及其意义。方法采用酶联免疫吸附检测法测定116例CHD慢性心力衰竭患者(CHF组)和44例正常体检者（对照组）血清中OPG与IGF-I水平，进行对照分析。结果 CHF组患者血清OPG水平显著高于正常对照组（68.94±12.08）pg/mL，且随着心功能的恶化而显著增高（P<0.01）；血清IGF-水平显著低于正常对照组（118.80±35.19）pg/mL，且随着心功能的恶化而显著降低（P<0.01）。血清中OPG与IGF-I水平呈负相关（r=-0.625，P<0.01）。结论 OPG与IGF-I共同参与了冠心病的心力衰竭的发生发展过程，二者的血清水平可以作为判断心力衰竭严重程度的指标。
目的：探討冠心病(congenital heart disease,CHD)心力衰竭患者血清中骨保護素(osteoprotegerin，OPG)和胰島素樣生長因子(insulin-like growth factor-I，IGF-I)的水平變化及其意義。方法採用酶聯免疫吸附檢測法測定116例CHD慢性心力衰竭患者(CHF組)和44例正常體檢者（對照組）血清中OPG與IGF-I水平，進行對照分析。結果 CHF組患者血清OPG水平顯著高于正常對照組（68.94±12.08）pg/mL，且隨著心功能的噁化而顯著增高（P<0.01）；血清IGF-水平顯著低于正常對照組（118.80±35.19）pg/mL，且隨著心功能的噁化而顯著降低（P<0.01）。血清中OPG與IGF-I水平呈負相關（r=-0.625，P<0.01）。結論 OPG與IGF-I共同參與瞭冠心病的心力衰竭的髮生髮展過程，二者的血清水平可以作為判斷心力衰竭嚴重程度的指標。
목적：탐토관심병(congenital heart disease,CHD)심력쇠갈환자혈청중골보호소(osteoprotegerin，OPG)화이도소양생장인자(insulin-like growth factor-I，IGF-I)적수평변화급기의의。방법채용매련면역흡부검측법측정116례CHD만성심력쇠갈환자(CHF조)화44례정상체검자（대조조）혈청중OPG여IGF-I수평，진행대조분석。결과 CHF조환자혈청OPG수평현저고우정상대조조（68.94±12.08）pg/mL，차수착심공능적악화이현저증고（P<0.01）；혈청IGF-수평현저저우정상대조조（118.80±35.19）pg/mL，차수착심공능적악화이현저강저（P<0.01）。혈청중OPG여IGF-I수평정부상관（r=-0.625，P<0.01）。결론 OPG여IGF-I공동삼여료관심병적심력쇠갈적발생발전과정，이자적혈청수평가이작위판단심력쇠갈엄중정도적지표。
ObjectiveTo explore the changes and significance of serum levels of osteoprotegerin (OPG) and insulin-like growth factor-Ⅰ(IGF-I) in patients with chronic heart failure(CHF) and coronary heart dis-ease(CHD).MethodsEnzyme-linked immunosorbentassay(ELISA) was used to determine serum levels of OPGand IGF-I in 116 patients with CHFand CHD and 44 healthy subjects.Comparative analysis was taken. ResultsSerum OPGin CHFgroup was obviously higher than that in normal control groups(68.94±12.08)pg/mL,and increased with the deterioration of cardiac function obviously (P<0.01).Serum IGF-Iin CHFgroup was obviously lower than that in normal control group(118.80±35.19)pg/mL,and decreased with deterioration of cardiac function obviously (P<0.01).Serum OPG was negatively related with IGF-I(r=-0.625,P<0.01). ConclusionOPGand IGF-I conjointly participate in the occurrence and development of CHD and heart failure.Serum levels of OPGand IGF-I can be used as the indicators for assessing the severity of heart failure.
