CAJ | 학술논문

目的：观测血清胃肠激素及循环血微核醣核酸（ microRNA）与急性胰腺炎的关系。方法2013年6月—2014年5月诊治急性胰腺炎患者70例为观察组，同时期的70例体检健康且同龄者为健康对照组，将2组的血清胃肠激素及循环血microRNA水平进行检测与比较，同时比较其在轻度、中度、重度及危重度急性胰腺炎患者中的差异及相关性。结果观察组患者血清胃泌素（ GAS）及血管活性肠肽（ VIP）均高于对照组，血清胃动素（ MTL）及胆囊收缩素（CCK）则均低于对照组，miR216a、miR155及miR196a均高于对照组，而miR－21则低于对照组，且轻度、中度、重度及危重度急性胰腺炎患者的检测水平也存在显著性差异（ P ＜0．05），经Logistic分析显示GAS、VIP、MTL、CCK、miR216a、miR155、miR196a、miR－21与急性胰腺炎均有密切关系（ P ＜0．05）。结论多项血清胃肠激素及循环血mi－croRNA与急性胰腺炎有密切关系，可作为本病诊断及治疗的依据。
목적：관측혈청위장격소급순배혈미핵당핵산（ microRNA）여급성이선염적관계。방법2013년6월—2014년5월진치급성이선염환자70례위관찰조，동시기적70례체검건강차동령자위건강대조조，장2조적혈청위장격소급순배혈microRNA수평진행검측여비교，동시비교기재경도、중도、중도급위중도급성이선염환자중적차이급상관성。결과관찰조환자혈청위비소（ GAS）급혈관활성장태（ VIP）균고우대조조，혈청위동소（ MTL）급담낭수축소（CCK）칙균저우대조조，miR216a、miR155급miR196a균고우대조조，이miR－21칙저우대조조，차경도、중도、중도급위중도급성이선염환자적검측수평야존재현저성차이（ P ＜0．05），경Logistic분석현시GAS、VIP、MTL、CCK、miR216a、miR155、miR196a、miR－21여급성이선염균유밀절관계（ P ＜0．05）。결론다항혈청위장격소급순배혈mi－croRNA여급성이선염유밀절관계，가작위본병진단급치료적의거。
Objective To observe the relationship between serum gastrointestinal hormones, circulating blood RNA ( microRNA) and acute pancreatitis.Methods From 2013 June to 2014 May, acute pancreatitis patients with 70 cases were enrolled as the observation group, at the same period, 70 cases of healthy people were enrolled as healthy control group, ser-um gastrointestinal hormones and circulating microRNA levels were detected and compared between the two groups, and com-pared the difference and correlation among the mild, moderate, severe and most severity group.Results Serum GAS and va-soactive intestinal peptide (VIP) in the observation group were higher than those in the control group, the serum motilin (MTL) and cholecystokinin (CCK) were lower than that of control group, miR216a, miR155 and miR196a were higher than those in the control group, while miR-21 was lower than that of the control group, and the level of these indices in the mild moderate, severe, and most severity groups were significant difference ( P <0.05), the Logistic analysis showed that GAS, VIP, MTL, CCK, miR216a, miR155, miR196a, and miR-21 were closely correlated with acute pancreatitis ( P <0.05). Conclusion There is a close relationship between serum gastrointestinal hormones, circulating microRNA and acute pancrea-titis;they can be used as the basis for disease diagnosis and treatment.