CAJ | 학술논문

目的：观察复方谷氨酰胺联合美莎拉嗪治疗非特异性小肠溃疡的临床疗效。方法选取收治的非特异性小肠溃疡患者72例，按照随机数字法分为2组各36例，观察组采用复方谷氨酰胺联合美莎拉嗪治疗，对照组采用复方谷氨酰胺治疗，均4周为1个疗程。观察患者治疗前后的肠道症状，记录2组患者腹泻、腹痛和腹胀发生次数，评价各组症状改善情况和临床疗效。结果治疗4周后，观察组总有效率为97．2％，明显高于对照组的80．5％（χ2＝20．71， P ＜0．05）。治疗2、4周后，2组患者平均腹泻次数减少（ t 对＝3．95、3．76， t 观＝3．23、3．11， P均＜0．05），且观察组优于对照组（ t ＝2．36、2．41， P ＜0．05）；2组患者腹痛、腹胀和腹泻症状积分较治疗前明显减轻（t对＝6．18、4．07、4．26， t 观＝6．31、4．52、4．76， P均＜0．05），且观察组效果明显优于对照组（ t ＝2．97、2．65、2．58， P均＜0．05）。与治疗前比较，治疗后血清TNF－α、IL－6、IL－8水平2组下降（ t 观＝4．35、4．51、4．43， t 对＝4．18、4．45、4．37， P均＜0．05），观察组患者血清TNF－α、IL－6、IL－8水平明显低于对照组（ t ＝2．85、2．91、3．19， P均＜0．05）。结论复方谷氨酰胺联合美莎拉嗪治疗非特异性小肠溃疡效果明显，疗效确切，值得临床推广应用。
목적：관찰복방곡안선알연합미사랍진치료비특이성소장궤양적림상료효。방법선취수치적비특이성소장궤양환자72례，안조수궤수자법분위2조각36례，관찰조채용복방곡안선알연합미사랍진치료，대조조채용복방곡안선알치료，균4주위1개료정。관찰환자치료전후적장도증상，기록2조환자복사、복통화복창발생차수，평개각조증상개선정황화림상료효。결과치료4주후，관찰조총유효솔위97．2％，명현고우대조조적80．5％（χ2＝20．71， P ＜0．05）。치료2、4주후，2조환자평균복사차수감소（ t 대＝3．95、3．76， t 관＝3．23、3．11， P균＜0．05），차관찰조우우대조조（ t ＝2．36、2．41， P ＜0．05）；2조환자복통、복창화복사증상적분교치료전명현감경（t대＝6．18、4．07、4．26， t 관＝6．31、4．52、4．76， P균＜0．05），차관찰조효과명현우우대조조（ t ＝2．97、2．65、2．58， P균＜0．05）。여치료전비교，치료후혈청TNF－α、IL－6、IL－8수평2조하강（ t 관＝4．35、4．51、4．43， t 대＝4．18、4．45、4．37， P균＜0．05），관찰조환자혈청TNF－α、IL－6、IL－8수평명현저우대조조（ t ＝2．85、2．91、3．19， P균＜0．05）。결론복방곡안선알연합미사랍진치료비특이성소장궤양효과명현，료효학절，치득림상추엄응용。
Objective To investigate the clinical efficacy of glutamine compound joint mesalamine in treatment of nonspecific small ulcer.Methods Selected 72 cases of non specific small ulcer patients, they were randomly divided into two groups with 36 patients in each group, the observation group were used Sarah triazine compound joint US glutamine treatment, the control group received glutamine compound treatment, four weeks as a course of treatment, observation intestinal symptoms in patients before and after treatment, diarrhea, abdominal pain and bloating of patients were recorded, improvement of symp-toms and clinical efficacy were evaluated.Results After four weeks of treatment, observation and control groups’ total effi-ciency were 97.2%and 80.5%respectively, the total efficiency of the observation group was significantly higher than that of control group (χ2 =20.71, P <0.05).After two and four weeks of treatment, diarrhea were reduced in both of the two groups (control group:t =3.95, t =3.76, observation group:t =3.23, t =3.11, P <0.05), observation group was better than control group ( t =2.36, t =2.41, P <0.05) .Abdominal pain, bloating and diarrhea were relieved than before treat-ment in both group (control group:t =6.18, t =4.07, t =4.26, observation group:t =6.31, t =4.52, t =4.76, P <0.05), and observation group was better than that of control group ( t =2.97, t =2.65, t =2.58, P <0.05).Compared with before treatment, serum TNF-α, IL-6, IL-8 levels were decreased in both of the two groups ( observation group:t =4.35, t =4.51, t =4.43, control group:t =4.18, t =4.45, t =4.37, P <0.05), observation group were significantly lower than that of the control group, the difference was statistically significant ( t =2.85, t =2.91, t =3.19, P <0.05). Conclusion Sarah triazine compound glutamine joint US in treatment of nonspecific small ulcer effect has obvious effect, its worthy of clinical application.