CAJ | 학술논문

目的：探讨共焦显微镜对真菌性角膜炎药物治疗后转归的临床观察。方法32例（32只眼）真菌性角膜炎的住院患者给予抗真菌性角膜炎药物治疗，在接受治疗的2w、4w、8w分别对患者进行共焦显微镜检查，根据真菌菌丝的数量、大小，临床体征调整用药。结果32例患者中28例治愈，视力不同程度提高，在治疗2月后复查共焦显微，患者病情稳定，仅见少量真菌菌丝或真菌菌丝完全消退，可见疤痕样改变，4例治疗2周后病情恶化，角膜穿孔，最终眼球摘除，治疗后总有效率为87．5％，有统计学意义（ P＜0．05）。结论共焦显微镜作为一种无创伤性诊疗手段，可作为指导真菌性角膜炎药物治疗的一种客观检查工具。
목적：탐토공초현미경대진균성각막염약물치료후전귀적림상관찰。방법32례（32지안）진균성각막염적주원환자급여항진균성각막염약물치료，재접수치료적2w、4w、8w분별대환자진행공초현미경검사，근거진균균사적수량、대소，림상체정조정용약。결과32례환자중28례치유，시력불동정도제고，재치료2월후복사공초현미，환자병정은정，부견소량진균균사혹진균균사완전소퇴，가견파흔양개변，4례치료2주후병정악화，각막천공，최종안구적제，치료후총유효솔위87．5％，유통계학의의（ P＜0．05）。결론공초현미경작위일충무창상성진료수단，가작위지도진균성각막염약물치료적일충객관검사공구。
Objective To investigate the clinical observation of fungal keratitis after drug treatment outcomes with confocal microscopy.Methods 32 patients (32 eyes) with fungal keratitis hospitalized patients given anti -drug treat-ment of fungal keratitis in treated 2 w, 4 w, 8 w, respectively , for patients confocal microscopy , depending on the num-ber of fungal hyphae , size, clinical signs adjust medication.Results All of patients were cured 28 cases, varying de-grees of visual acuity improved after treatment in 8w to review confocal microscopy , the patient′s condition is stable , only see a small amount of fungal hyphae or fungal hyphae completely subsided , visible scar -like changes , 4 cases of the disease after treatment 2 w deterioration, corneal perforation, final enucleation after treatment , the total effective rate was 87.5%, with statistical significance (P<0.05).Conclusions Confocal microscopy as a non -invasive treatment meth-ods, can be used as medication guide fungal keratitis an objective examination tool .