CAJ | 학술논문

目的：应用Meta分析探讨丙型肝炎病毒感染与胆管细胞癌（CCA）发生风险的关系。方法在中国知网、PubMed、EMBASE、MEDLINE数据库检索2013年8月前正式发表的文献。英文检索关键词主要包括hepatitis C virus、HCV、cholangiocarcinoma、bile duct cancer、intrahepatic、extrahepatic。中文检索关键词主要包括丙型肝炎病毒、胆管癌、肝内胆管细胞癌、肝外胆管癌，辅以手工检索查找相关文献。将文献数据合并后，分别分析丙型肝炎病毒感染与CCA、肝内胆管细胞癌（ICC）、肝外胆管癌（ECC）发生风险的关系。采用Q 检验进行文献异质性检验。计算各研究及合并数据的RR 值，绘制森林图，显示各研究结果及其特征。采用漏斗图和Egger法检验文献发表偏倚。结果经筛选纳入18篇文献，包括16篇病例对照研究和2篇队列研究文献，共计873501例患者纳入分析。Meta分析显示丙型肝炎病毒感染与CCA发生无关（RR=2.36，P>0.05），丙型肝炎病毒感染为ICC和ECC发生的危险因素（RR=4.10，1.48；P<0.05）。漏斗图和Egger法检验显示文献发表无偏倚。结论丙型肝炎病毒感染会明显增加ICC和ECC的发生风险，但其与ICC发生的关系更为密切。
목적：응용Meta분석탐토병형간염병독감염여담관세포암（CCA）발생풍험적관계。방법재중국지망、PubMed、EMBASE、MEDLINE수거고검색2013년8월전정식발표적문헌。영문검색관건사주요포괄hepatitis C virus、HCV、cholangiocarcinoma、bile duct cancer、intrahepatic、extrahepatic。중문검색관건사주요포괄병형간염병독、담관암、간내담관세포암、간외담관암，보이수공검색사조상관문헌。장문헌수거합병후，분별분석병형간염병독감염여CCA、간내담관세포암（ICC）、간외담관암（ECC）발생풍험적관계。채용Q 검험진행문헌이질성검험。계산각연구급합병수거적RR 치，회제삼림도，현시각연구결과급기특정。채용루두도화Egger법검험문헌발표편의。결과경사선납입18편문헌，포괄16편병례대조연구화2편대렬연구문헌，공계873501례환자납입분석。Meta분석현시병형간염병독감염여CCA발생무관（RR=2.36，P>0.05），병형간염병독감염위ICC화ECC발생적위험인소（RR=4.10，1.48；P<0.05）。루두도화Egger법검험현시문헌발표무편의。결론병형간염병독감염회명현증가ICC화ECC적발생풍험，단기여ICC발생적관계경위밀절。
ObjectiveTo explore the correlation between hepatitis C virus infection and the risk of cholangiocarcinoma (CCA) through Meta-analysis.MethodsLiteratures that were formally published prior to August, 2013 were searched on National Knowledge Infrastructure (CNKI), PubMed, EMBASE and MEDLINE databases using English, Chinese terms mainly including hepatitis C virus, HCV, cholangiocarcinoma, bile duct cancer, intrahepatic, extrahepatic. Moreover, associated literatures were also searched by manual searching. Data from the literatures were merged and the correlation between hepatitis C virus and risk of CCA, intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (ECC) was analyzed respectively. Heterogeneity test was conducted usingQ test.RR value of each study and pooled data were calculated and forest graph was drawn to display the results and features of each study. Funnel plot and Egger test were used to identify the publication bias.ResultsA total of 16 case-control studies and 2 cohort studies (total 873 501 patients) were included in the ifnal analysis. Meta-analysis showed that hepatitis C virus infection was not associated with the occurrence of CCA (RR=2.36,P>0.05) and hepatitis C virus infection was the risk factor for the occurrence of ICC and ECC (RR=4.10, 1.48;P<0.05).Funnel plot and Egger test showed no evidence for publication bias.ConclusionHepatitis C virus infection is associated with the risks of ICC and ECC, especially ICC.