CAJ | 학술논문

目的：：观察曲马多复合对乙酰氨基酚栓剂防治小儿七氟醚全麻苏醒期躁动的效果。方法：择期七氟醚全麻下手术患儿90例随机分为3组，每组各30例。3组均用8％七氟醚、芬太尼2μg/kg和维库溴铵0.1 mg/kg全麻诱导，术中以七氟醚(1~1.5 MAC)维持麻醉。 A组：术前10 min对乙酰氨基酚栓剂20 mg/kg塞肛＋手术结束前20 min静注曲马多1 mg/kg；B组：手术结束前20 min静注曲马多2 mg/kg；C组：手术结束前20 min静注等量生理盐水。观察3组手术时间，术后清醒时间、拔管时间、镇静评分、躁动发生情况及药物不良反应。结果：3组手术时间、清醒时间、拔管时间等指标比较，差异无统计学意义(P>0.05)。 A组躁动发生率、恶心呕吐发生率和躁动评分明显低于B组和C组，而Remesay镇静评分明显高于B组和C组( P<0.05)，结论：曲马多1 mg/kg复合对乙酰氨基酚栓剂20 mg/kg用于防治小儿七氟醚全麻苏醒期躁动安全有效。
목적：：관찰곡마다복합대을선안기분전제방치소인칠불미전마소성기조동적효과。방법：택기칠불미전마하수술환인90례수궤분위3조，매조각30례。3조균용8％칠불미、분태니2μg/kg화유고추안0.1 mg/kg전마유도，술중이칠불미(1~1.5 MAC)유지마취。 A조：술전10 min대을선안기분전제20 mg/kg새항＋수술결속전20 min정주곡마다1 mg/kg；B조：수술결속전20 min정주곡마다2 mg/kg；C조：수술결속전20 min정주등량생리염수。관찰3조수술시간，술후청성시간、발관시간、진정평분、조동발생정황급약물불량반응。결과：3조수술시간、청성시간、발관시간등지표비교，차이무통계학의의(P>0.05)。 A조조동발생솔、악심구토발생솔화조동평분명현저우B조화C조，이Remesay진정평분명현고우B조화C조( P<0.05)，결론：곡마다1 mg/kg복합대을선안기분전제20 mg/kg용우방치소인칠불미전마소성기조동안전유효。
Objective:To investigate the effects of tramadol combined with acetaminophen suppository for the prevention of emergence agitation in children undergoing sevoflurane general anesethesia. Methods: Ninety children, who underwent elective operation with sevoflurane general anesthesia, were randomly divided into 3 groups, with 30 cases in each group. All the 3 groups received 8% sevoflurane, 2μg/kg fentanyl and 0.1 mg/kg vecuronium for general anesthesia induction. And with the sevoflurane ( 1~1. 5MAC ) was used to maintain anesthesia during operation. Group A received 20 mg/kg acetaminophen suppository in anus at 10min before the operation and 1mg/kg intravenous injection of tramadol at 20 min before the end of the operation. Group B received intravenous injection of 2mg/kg tramadol at 20 min before the end of surgery. Group C received intravenous injection of equivalent normal saline at 20 min before the end of surgery. The operation time, postoperative waking time, extubation time, sedation score, agitation occurrence and adverse drug reactions in the three groups were observed and recorded. Results: There were no statistically significant differences in the operation time, waking time and extubation time among the three groups ( P>0.05) . The incidence of agitation, nausea and vomiting, and agitation score in group A were significantly lower than those in group B and group C. However, the Remesay sedation score in group A was significantly higher than that in group B and group C ( P<0.05) . Conclusion:The effects of 1mg/kg of tramadol combined with 20mg/kg of acetaminophen suppository for the prevention of emergence agitation in children undergoing sevoflurane general anesethesia were safe and effective.