中华核医学与分子影像杂志
中華覈醫學與分子影像雜誌
중화핵의학여분자영상잡지
Chinese Journal of Nuclear Medicine and Molecular Imaging
2015年
1期
14-17
,共4页
巨淋巴结增生%体层摄影术,发射型计算机%体层摄影术,X线计算机%脱氧葡萄糖
巨淋巴結增生%體層攝影術,髮射型計算機%體層攝影術,X線計算機%脫氧葡萄糖
거림파결증생%체층섭영술,발사형계산궤%체층섭영술,X선계산궤%탈양포도당
Giant lymph node hyperplasia%Tomography,emission-computed%Tomography,X-ray computed%Deoxyglucose
目的 探讨Castleman病(CD)的18F-FDG PET/CT显像特点.方法 回顾性分析经病理确诊的12例初诊CD患者的18F-FDG PET/CT显像及临床资料,其中男7例,女5例,平均年龄(51.2±19.3)岁.将SUVmax大于正常肝脏SUVmax的病灶定义为阳性;测量阳性病灶的大小(短径),并与SUVmax进行Pearson相关分析.根据临床分类、病理类型及有无临床症状进行分组,采用Mann-Whitney秩和检验对各组的SUVmax进行比较.结果 12例CD患者中7例为局灶型CD(LCD),病变侵犯单一部位淋巴结;5例为多中心型CD(MCD),病变侵犯多部位淋巴结,部分伴有肺部及脾脏浸润.12例患者有129个阳性病灶(LCD 7个,MCD 122个),平均SUVmax4.20±1.84(2.50～ 10.70),病灶的大小与SUVmax未见相关性(r=0.189,P＞0.05).LCD和MCD的SUVmax分别为4.23±1.77和4.19± 1.86,差异无统计学意义(Z=-0.108,P＞0.05);透明血管型CD的SUVmax为3.63±0.89,浆细胞型CD的SUVmax为4.26±1.91,差异无统计学意义(Z=-0.519,P＞0.05).有临床症状CD的SUVmax为4.56±2.06,无临床症状CD的SUVmax为3.41±0.87,差异有统计学意义(Z=-2.443,P＜0.05).结论 CD以淋巴结侵犯为主,病灶的18 F-FDG代谢增高,且代谢增高程度与临床分类及病理类型无关.
目的 探討Castleman病(CD)的18F-FDG PET/CT顯像特點.方法 迴顧性分析經病理確診的12例初診CD患者的18F-FDG PET/CT顯像及臨床資料,其中男7例,女5例,平均年齡(51.2±19.3)歲.將SUVmax大于正常肝髒SUVmax的病竈定義為暘性;測量暘性病竈的大小(短徑),併與SUVmax進行Pearson相關分析.根據臨床分類、病理類型及有無臨床癥狀進行分組,採用Mann-Whitney秩和檢驗對各組的SUVmax進行比較.結果 12例CD患者中7例為跼竈型CD(LCD),病變侵犯單一部位淋巴結;5例為多中心型CD(MCD),病變侵犯多部位淋巴結,部分伴有肺部及脾髒浸潤.12例患者有129箇暘性病竈(LCD 7箇,MCD 122箇),平均SUVmax4.20±1.84(2.50～ 10.70),病竈的大小與SUVmax未見相關性(r=0.189,P＞0.05).LCD和MCD的SUVmax分彆為4.23±1.77和4.19± 1.86,差異無統計學意義(Z=-0.108,P＞0.05);透明血管型CD的SUVmax為3.63±0.89,漿細胞型CD的SUVmax為4.26±1.91,差異無統計學意義(Z=-0.519,P＞0.05).有臨床癥狀CD的SUVmax為4.56±2.06,無臨床癥狀CD的SUVmax為3.41±0.87,差異有統計學意義(Z=-2.443,P＜0.05).結論 CD以淋巴結侵犯為主,病竈的18 F-FDG代謝增高,且代謝增高程度與臨床分類及病理類型無關.
목적 탐토Castleman병(CD)적18F-FDG PET/CT현상특점.방법 회고성분석경병리학진적12례초진CD환자적18F-FDG PET/CT현상급림상자료,기중남7례,녀5례,평균년령(51.2±19.3)세.장SUVmax대우정상간장SUVmax적병조정의위양성;측량양성병조적대소(단경),병여SUVmax진행Pearson상관분석.근거림상분류、병리류형급유무림상증상진행분조,채용Mann-Whitney질화검험대각조적SUVmax진행비교.결과 12례CD환자중7례위국조형CD(LCD),병변침범단일부위림파결;5례위다중심형CD(MCD),병변침범다부위림파결,부분반유폐부급비장침윤.12례환자유129개양성병조(LCD 7개,MCD 122개),평균SUVmax4.20±1.84(2.50～ 10.70),병조적대소여SUVmax미견상관성(r=0.189,P＞0.05).LCD화MCD적SUVmax분별위4.23±1.77화4.19± 1.86,차이무통계학의의(Z=-0.108,P＞0.05);투명혈관형CD적SUVmax위3.63±0.89,장세포형CD적SUVmax위4.26±1.91,차이무통계학의의(Z=-0.519,P＞0.05).유림상증상CD적SUVmax위4.56±2.06,무림상증상CD적SUVmax위3.41±0.87,차이유통계학의의(Z=-2.443,P＜0.05).결론 CD이림파결침범위주,병조적18 F-FDG대사증고,차대사증고정도여림상분류급병리류형무관.
Objective To evaluate the imaging characteristics of 18 F-FDG PET/CT in patients with Castleman's disease (CD).Methods Twelve patients (male 7,female 5,mean age:(51.2±19.3)years) with pathologically confirmed CD and 18F-FDG PET/CT were retrospectively enrolled.A lesion with SUVmax greater than that of normal liver tissue was defined as positive.Lesion size (short diameter) was measured.Correlation between size and SUVmax was analyzed by Pearson correlation analysis.SUVmax of different clinical and pathological types was compared using Mann-Whitney rank sum test.Results Among 12patients,7 patients had localized CD (LCD) involving a single group of lymph nodes and 5 patients had multicentric CD (MCD) involving more than one group of lymph nodes with some having lung and spleen infiltration.A total of 129 positive lesions were found (7 of LCD,122 of MCD) and the average SUVmax was 4.20±1.84 (range:2.50 to 10.70).There was no significant correlation between SUVmax and lesion size (r =0.189,P＞0.05).There was no significant difference in SUVmax between LCD and MCD (4.23±1.77 vs 4.19±1.86; Z=-0.108,P＞0.05) ; but there was significant difference in SUVmax between the patients with and without clinical manifestations (4.56±2.06 vs 3.41±0.87; Z=-2.443,P＜0.05).No significant difference was found between SUVmax of hyaline vascular CD and plasma cell CD (3.63±0.89 vs 4.26±1.91; Z=-0.519,P＞0.05).Conclusions CD shows primarily lymph node involvement with increased 18F-FDG uptake.However,the degree of FDG uptake does not correlate with clinical presentation or pathological types.
