中华核医学与分子影像杂志
中華覈醫學與分子影像雜誌
중화핵의학여분자영상잡지
Chinese Journal of Nuclear Medicine and Molecular Imaging
2015年
1期
5-9
,共5页
郭悦%陈聪霞%李文婵%屈婉莹%姚稚明%刘甫庚
郭悅%陳聰霞%李文嬋%屈婉瑩%姚稚明%劉甫庚
곽열%진총하%리문선%굴완형%요치명%류보경
肺肿瘤%体层摄影术,发射型计算机%体层摄影术,X线计算机%脱氧葡萄糖
肺腫瘤%體層攝影術,髮射型計算機%體層攝影術,X線計算機%脫氧葡萄糖
폐종류%체층섭영술,발사형계산궤%체층섭영술,X선계산궤%탈양포도당
Lung neoplasms%Tomography,emission-computed%Tomography,X-ray computed%Deoxyglucose
目的 探讨18F-FDG PET/CT对肺非实性结节的诊断价值.方法 回顾性分析经手术病理或随访证实的44例患者[男35例,女9例,年龄(68.05±9.89)岁]的49个非实性结节的18F-FDGPET/CT影像资料,其中纯磨玻璃结节(pGGN)28个,部分实性结节(PSN) 21个;测量病灶最大径(dmax)、磨玻璃成分(GGO)百分比、SUVmax及延迟显像的滞留指数(RI);用目测法判断PET的阳性率.SUVmax与病灶dmax及GGO百分比的相关性用Pearson相关分析,良、恶性结节SUVmax及恶性pGGN和PSN的SUVmax的比较用两样本t检验,率的比较采用x2检验.结果 (1)49个结节中,良性6个,均为pGGN;恶性43个,其中pGGN 22个,PSN 21个.(2)PSN的SUVmax与病灶dmax呈正相关(r=0.500,P＜0.05),与GGO百分比呈负相关(r=-0.605,P＜0.05);pGGN的SUVmax与病灶dmax呈正相关(r=0.375,P＜0.05).(3)6个良性pGGN的SUVmax平均值为0.78±0.25(0.50 ～ 1.20),22个恶性pGGN的SUVmax平均值为0.91±0.34(0.40～1.70),差异无统计学意义(t=-0.813,P＞0.05);21个恶性PSN的SUVmax平均值为2.10±1.16(0.60～5.60),高于恶性pGGN(t=-4.645,P＜0.05).(4)以目测代谢活性高于或等于纵隔血池为恶性判定标准,PET对恶性PSN的诊断准确性为66.7％(14/21),明显高于恶性pGGN的9.1％(2/22; x2=15.244,P＜0.05);以RI＞10％为恶性判定标准,pGGN及PSN的诊断准确性分别为45.8％ (11/24)和65.0％ (13/20),差异无统计学意义(x2=1.616,P＞0.05).结论 18F-FDG PET/CT对于pGGN较单独CT无明显诊断优势,而对于PSN则具有较好的诊断价值.
目的 探討18F-FDG PET/CT對肺非實性結節的診斷價值.方法 迴顧性分析經手術病理或隨訪證實的44例患者[男35例,女9例,年齡(68.05±9.89)歲]的49箇非實性結節的18F-FDGPET/CT影像資料,其中純磨玻璃結節(pGGN)28箇,部分實性結節(PSN) 21箇;測量病竈最大徑(dmax)、磨玻璃成分(GGO)百分比、SUVmax及延遲顯像的滯留指數(RI);用目測法判斷PET的暘性率.SUVmax與病竈dmax及GGO百分比的相關性用Pearson相關分析,良、噁性結節SUVmax及噁性pGGN和PSN的SUVmax的比較用兩樣本t檢驗,率的比較採用x2檢驗.結果 (1)49箇結節中,良性6箇,均為pGGN;噁性43箇,其中pGGN 22箇,PSN 21箇.(2)PSN的SUVmax與病竈dmax呈正相關(r=0.500,P＜0.05),與GGO百分比呈負相關(r=-0.605,P＜0.05);pGGN的SUVmax與病竈dmax呈正相關(r=0.375,P＜0.05).(3)6箇良性pGGN的SUVmax平均值為0.78±0.25(0.50 ～ 1.20),22箇噁性pGGN的SUVmax平均值為0.91±0.34(0.40～1.70),差異無統計學意義(t=-0.813,P＞0.05);21箇噁性PSN的SUVmax平均值為2.10±1.16(0.60～5.60),高于噁性pGGN(t=-4.645,P＜0.05).(4)以目測代謝活性高于或等于縱隔血池為噁性判定標準,PET對噁性PSN的診斷準確性為66.7％(14/21),明顯高于噁性pGGN的9.1％(2/22; x2=15.244,P＜0.05);以RI＞10％為噁性判定標準,pGGN及PSN的診斷準確性分彆為45.8％ (11/24)和65.0％ (13/20),差異無統計學意義(x2=1.616,P＞0.05).結論 18F-FDG PET/CT對于pGGN較單獨CT無明顯診斷優勢,而對于PSN則具有較好的診斷價值.
목적 탐토18F-FDG PET/CT대폐비실성결절적진단개치.방법 회고성분석경수술병리혹수방증실적44례환자[남35례,녀9례,년령(68.05±9.89)세]적49개비실성결절적18F-FDGPET/CT영상자료,기중순마파리결절(pGGN)28개,부분실성결절(PSN) 21개;측량병조최대경(dmax)、마파리성분(GGO)백분비、SUVmax급연지현상적체류지수(RI);용목측법판단PET적양성솔.SUVmax여병조dmax급GGO백분비적상관성용Pearson상관분석,량、악성결절SUVmax급악성pGGN화PSN적SUVmax적비교용량양본t검험,솔적비교채용x2검험.결과 (1)49개결절중,량성6개,균위pGGN;악성43개,기중pGGN 22개,PSN 21개.(2)PSN적SUVmax여병조dmax정정상관(r=0.500,P＜0.05),여GGO백분비정부상관(r=-0.605,P＜0.05);pGGN적SUVmax여병조dmax정정상관(r=0.375,P＜0.05).(3)6개량성pGGN적SUVmax평균치위0.78±0.25(0.50 ～ 1.20),22개악성pGGN적SUVmax평균치위0.91±0.34(0.40～1.70),차이무통계학의의(t=-0.813,P＞0.05);21개악성PSN적SUVmax평균치위2.10±1.16(0.60～5.60),고우악성pGGN(t=-4.645,P＜0.05).(4)이목측대사활성고우혹등우종격혈지위악성판정표준,PET대악성PSN적진단준학성위66.7％(14/21),명현고우악성pGGN적9.1％(2/22; x2=15.244,P＜0.05);이RI＞10％위악성판정표준,pGGN급PSN적진단준학성분별위45.8％ (11/24)화65.0％ (13/20),차이무통계학의의(x2=1.616,P＞0.05).결론 18F-FDG PET/CT대우pGGN교단독CT무명현진단우세,이대우PSN칙구유교호적진단개치.
Objective To determine the value of 18F-FDG PET/CT in the detection of subsolid pulmonary nodules.Methods The 18F-FDG PET/CT imaging data of 44 patients (35 males,9 females,mean age (68.05±9.89) years) with 49 subsolid pulmonary nodules were retrospectively analyzed.There were 28 pure ground-glass nodules (pGGN) and 21 part-solid nodules (PSN),which were all confirmed by postsurgical pathology or imaging results during follow-up.The lesion size (dmax),ground-glass opacity (GGO) percentage,SUV retention index (RI),and the positive rates on PET images were accessed.The correlation between SUVmax and lesion size and GGO percentage was analyzed by Pearson correlation analysis.The SUVmax between benign and malignant pGGN,and that between malignant pGGN and PSN,were compared using two-sample t test.The diagnostic accuracy was compared using x2 test.Results (1) Six pGGN were benign while 43 nodules (including 22 pGGN and 21 PSN) were malignant among the 49 nodules.(2) SUVmax was positively correlated with lesion size (r=0.500,P＜0.05) and was negatively correlated with GGO percentage (r=-0.605,P＜0.05) for PSN,while SUVmax was positively correlated with lesion size (r=0.375,P＜0.05) for pGGN.(3) SUVmax was not significantly different (t =-0.813,P＞0.05) between 6 benign pGGN (0.78±0.25,range:0.50-1.20) and 22 malignant pGGN (0.91±0.34,range:0.40-1.70);SUVmax of 21 malignant PSN (2.10±1.16,range:0.60-5.60) was higher than that of 22 malignant pGGN (t=-4.645,P＜0.05).(4) When a nodule's activity being equal to or greater than that of mediastinal blood-pool was defined as malignancy,the accuracy rate of PSN (66.7％,14/21) was significantly higher than that of pGGN (9.1％,2/22; x2 =15.244,P ＜0.05).Based on the criteria for malignancy of RI＞10％,the accuracy rates for PSN and pGGN were 65.0％ (13/20) and 45.8％ (11/24),respectively (x2 =1.616,P＞0.05).Conclusion 18F-FDG PET/CT shows no clear advantage for diagnosis of pGGN,but is helpful for PSN.
