CAJ | 학술논문

目的：研究阿立哌唑联合氟西汀治疗慢性精神分裂症的临床疗效及不良反应。方法随机选取58例慢性精神分裂症患者，分为对照组和实验组。对照组仅给阿立哌唑，实验组给以阿立哌唑联合氟西汀，经4个月的治疗后观察两组患者阴性症状的治疗效果。结果经治疗，实验组较对照组的阴性症状显著改善，PANSS总分、阴性评分、阳性评分及病理评分均有所降低；两组不良反应均较少，无显著性差异。结论阿立哌唑联合氟西汀用于慢性精神分裂症的治疗疗效显著，尤其阴性症状明显改善，不良反应轻，临床上可推广应用。
목적：연구아립고서연합불서정치료만성정신분렬증적림상료효급불량반응。방법수궤선취58례만성정신분렬증환자，분위대조조화실험조。대조조부급아립고서，실험조급이아립고서연합불서정，경4개월적치료후관찰량조환자음성증상적치료효과。결과경치료，실험조교대조조적음성증상현저개선，PANSS총분、음성평분、양성평분급병리평분균유소강저；량조불량반응균교소，무현저성차이。결론아립고서연합불서정용우만성정신분렬증적치료료효현저，우기음성증상명현개선，불량반응경，림상상가추엄응용。
Objective?To?study?the?clinical?efficacy?and?adverse?drug?reaction?of?aripiprazole?combined?with?fluoxetine?in?the?treatment?of?chronic?schizophrenia.?Method?To?select?58?patients?with?chronic?schizophrenia,?and?devide?into?control?group?and?experiment?group.?Results?After?treatment,?compared with control group, the negative symptoms of experiment group have got signiifcant improvement. The total scores of PANSS, positive score, negative score and pathological score have all been decreased. The adverse effects of the two groups are relatively mild, without signiifcant difference. Conclusion The clinical efifcacy of aripiprazole combined with lfuoxetine in the treatment of chronic schizophrenia is apparent, especially for negative symptoms;?with?fewer?adverse?effects,?it?is?suitable?for?clinical?application.