CAJ | 학술논문

目的探讨常规超声、超声造影及两者联合鉴别诊断甲状腺结节的价值。方法回顾性分析95例单发甲状腺结节患者的常规超声、超声造影资料，采用多元Logistic回归获得常规超声、超声造影及两者联合诊断甲状腺恶性结节的模型方程，计算3个模型诊断甲状腺恶性结节的准确率、敏感度和特异度，绘制ROC曲线评价3种方法诊断甲状腺恶性结节的能力。结果常规超声诊断甲状腺恶性结节的主要指标为形态不规则，砂粒样钙化及无声晕；超声造影诊断甲状腺恶性结节的主要指标为灌注时间快，弥漫性整体增强为主；常规超声联合超声造影诊断甲状腺恶性结节的主要指标为形态不规则，砂粒样钙化、无声晕及弥漫性整体增强；2种方法联合诊断甲状腺恶性结节的准确率、特异度、敏感度分别为91．4%、88．2%、96．6%，均高于单一的诊断方法。结论常规超声和超声造影二者联合应用可提高鉴别甲状腺结节良恶性的水平。
목적탐토상규초성、초성조영급량자연합감별진단갑상선결절적개치。방법회고성분석95례단발갑상선결절환자적상규초성、초성조영자료，채용다원Logistic회귀획득상규초성、초성조영급량자연합진단갑상선악성결절적모형방정，계산3개모형진단갑상선악성결절적준학솔、민감도화특이도，회제ROC곡선평개3충방법진단갑상선악성결절적능력。결과상규초성진단갑상선악성결절적주요지표위형태불규칙，사립양개화급무성훈；초성조영진단갑상선악성결절적주요지표위관주시간쾌，미만성정체증강위주；상규초성연합초성조영진단갑상선악성결절적주요지표위형태불규칙，사립양개화、무성훈급미만성정체증강；2충방법연합진단갑상선악성결절적준학솔、특이도、민감도분별위91．4%、88．2%、96．6%，균고우단일적진단방법。결론상규초성화초성조영이자연합응용가제고감별갑상선결절량악성적수평。
Objective To explore the value of conventional ultrasound , contrast-enhanced ultrasound and ul-trasound combined with contrast-enhanced ultrasound in differential diagnosis of benign and malignant thyroid nod-ules. Methods Ultrasonography ,contrast data of 95 patients with thyroid nodules were retrospectively analyzed. Multinomial Logistic regression was used to create the Logistic equations and to obtain the accuracy, specificity and sensitivity of conventional ultrasound ,contrast-enhanced ultrasound and conventional ultrasound combined with con-trast-enhanced ultrasound for diagnosing thyroid cancer. ROC curves for diagnosing thyroid cancer were drawn and the diagnostic abilities of the three methods were compared. Results Foliar margins, sand samples calcification and no halo for conventional ultrasound, quickly perfusion and homogeneous enhancement for contrast-enhanced ultra-sound, and Foliar margins, sand samples calcification , no halo and homogeneous enhancement for conventional ultra-sound combined with contrast-enhanced ultrasound were the main evidences for diagnosing thyroid cancer. The accu-racy , specificity and sensitivity of combination of the two methods was 91.4%, 88.2%, 96.6%. Which was higher than single method. Conclusion The abilities of conventional ultrasound and contrast-enhanced ultrasound in differential diagnosis of benign and malignant thyroid nodules were similar, combination of the two methods can improve the diag-nosticability.