CAJ | 학술논문

目的：探讨历代医家临床治疗老年性痴呆的中药组方配伍规律。方法以健忘、多忘、痴、呆为检索词,检索《中华医典》中相关文献,筛选方剂信息并进行标准化处理,构建数据库,通过频数分析及关联规则方法挖掘方剂的中药组成和配伍规律。结果共选出449首与治疗老年性痴呆相关的处方,涉及中药682味。方中出现频次最高的单味药为人参(192),药对为人参、远志(182),3味药物组合为茯神、人参、远志(79),4味药物组合为远志、人参、茯神、甘草(37),通过关联规则分析得出,人参-远志、人参-甘草、人参-茯神等为临床治疗老年性痴呆的方剂中常用配伍。结论历代医家治疗老年性痴呆选药以补益、安神药物为主,其配伍组合合理,具有一定代表性。
목적：탐토역대의가림상치료노년성치태적중약조방배오규률。방법이건망、다망、치、태위검색사,검색《중화의전》중상관문헌,사선방제신식병진행표준화처리,구건수거고,통과빈수분석급관련규칙방법알굴방제적중약조성화배오규률。결과공선출449수여치료노년성치태상관적처방,섭급중약682미。방중출현빈차최고적단미약위인삼(192),약대위인삼、원지(182),3미약물조합위복신、인삼、원지(79),4미약물조합위원지、인삼、복신、감초(37),통과관련규칙분석득출,인삼-원지、인삼-감초、인삼-복신등위림상치료노년성치태적방제중상용배오。결론역대의가치료노년성치태선약이보익、안신약물위주,기배오조합합리,구유일정대표성。
Objective To study the compatibility of TCM prescriptions of TCM practitioners of all dynasties of Alzheimer disease (AD). Methods Amnesia, forgetting, dementia, and idiot were set as search words to retrieve relevant literature in Encyclopadia of Traditional Chinese Medicine. Prescription information was screened and standardized to build database. Frequency analysis and association rules were used to mine TCM prescriptions and compatibility rules. Results Totally 449 AD related prescriptions were selected, involving 682 Chinese medicinal herbs. The individual herb with the highest frequency was Ginseng Radix Rhizoma (192);the herbal pair with the highest frequency was Ginseng Radix Rhizoma-Polyhalae Radix (182);the herbal combination with 3 Chinese medicinal herbs with the highest frequency was Poria with Hostwood-Ginseng Radix Rhizoma-Polyhalae Radix (79);the herbal combination with 4 Chinese medicinal herbs with the highest frequency was Polyhalae Radix-Ginseng Radix Rhizoma-Poria with Hostwood-Glycyrrhizae Radix et Rhizoma (37). The results of association rules showed that Ginseng Radix Rhizoma-Polyhalae Radix, Ginseng Radix Rhizoma-Glycyrrhizae Radix et Rhizoma, and Ginseng Radix Rhizoma-Poria with Hostwood were commonly used compatibilities in AD related prescriptions. Conclusion Treatment of TCM practitioners in all dynasties for AD mainly chooses Chinese medicinal herbs with the efficacy of tonifying qi and soothing nerves. The compatibilities and combinations are reasonable and with certain representativeness.