CAJ | 학술논문

目的：探索中药复方治疗中晚期非小细胞肺癌(NSCLC)的用药规律。方法检索中国生物医学文献数据库(CBM)、中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)公开发表的文献中治疗中晚期NSCLC的中药复方，建立相应数据库，采用频数分析、聚类分析、关联规则等方法对复方进行数据挖掘，对主要药物、药对(组)规律进行分析。结果在治疗中晚期NSCLC的107首中药复方中，涉及193味药物，使用频次为1298次，其中使用频次≥9次的药物有42种；42种药物的性味、归经分析发现，四气中以寒性最多(409频次)，五味中以甘味最多(627频次)，归经中以肺经为最多(546频次)。作为主要药物进行聚类分析，分为补阴药、清热药、补气药、补血药、活血药、止血药、化痰药、降气药、敛肺药共9类；经关联规则分析，共得药对规则26条，药组规则18条，主要为益气药、养阴药与清热药的配伍组合。结论治疗中晚期NSCLC中药复方用药以寒、平为主，甘、苦药居多，归经以肺、脾、胃经为主，治法以益气、养阴、解毒为主。
목적：탐색중약복방치료중만기비소세포폐암(NSCLC)적용약규률。방법검색중국생물의학문헌수거고(CBM)、중국지식자원총고(CNKI)、중국학술기간수거고(만방수거)공개발표적문헌중치료중만기NSCLC적중약복방，건립상응수거고，채용빈수분석、취류분석、관련규칙등방법대복방진행수거알굴，대주요약물、약대(조)규률진행분석。결과재치료중만기NSCLC적107수중약복방중，섭급193미약물，사용빈차위1298차，기중사용빈차≥9차적약물유42충；42충약물적성미、귀경분석발현，사기중이한성최다(409빈차)，오미중이감미최다(627빈차)，귀경중이폐경위최다(546빈차)。작위주요약물진행취류분석，분위보음약、청열약、보기약、보혈약、활혈약、지혈약、화담약、강기약、렴폐약공9류；경관련규칙분석，공득약대규칙26조，약조규칙18조，주요위익기약、양음약여청열약적배오조합。결론치료중만기NSCLC중약복방용약이한、평위주，감、고약거다，귀경이폐、비、위경위주，치법이익기、양음、해독위주。
Objective To study the medication regularity of compound herbal formulae in treating patients with advanced non-small lung cancer (NSCLC). Methods Compound herbal formulae published on journals for the treatment of NSCLC were searched and collected from CBM, CNKI, and Wanfang Data for database establishment. Frequency analysis, cluster analysis, and association rule analysis were used for data mining, and regularity of main Chinese medicinal herbs and herbal pairs (combinations) were investigated. Results There were 107 compound herbal formulae (involving 193 Chinese medicinal herbs and 1298 frequency) for NSCLC. 42 Chinese medicinal herbs were used for more than 9 times. Cluster analysis on the tastes and properties of the 42 Chinese medicinal herbs found that, among the four qi, cold showed the highest frequency (409);among the five tastes, sweet showed the highest frequency (627);among the meridians, lung meridian showed the highest frequency (546). Cluster analysis divided main Chinese medicinal herbs into 9 types, including yin-nourishing herbs, heat-clearing herbs, qi-tonifying herbs, blood-enriching herbs, blood circulation activating herbs, hemostasis herbs, phlegm-reducing herbs, qi-descending herbs, lung-astringing herbs. Associate rule analysis obtained 26 rules for Chinese medicinal herbal pairs, 18 rules for Chinese medicinal herbal combination, most of which were combinations for tonifying qi, nourishing yin, and clearing heat. Conclusion Chinese compound herbal formulae for the treatment of NSCLC mainly use Chinese medicinal herbs with properties of cold and mildness, with the tastes of sweet and bitter, with meridians of lung, spleen, and stomach, with the treatment of tonifying qi, nourishing yin, and detoxication.