CAJ | 학술논문

目的：观察加味当归贝母苦参丸辅助经肝动脉化疗栓塞术治疗原发性肝癌的临床疗效。方法将原发性肝癌患者84例随机分为联合治疗组和常规对照组各42例。常规对照组采用经肝动脉化疗栓塞术治疗，联合治疗组在此基础上给予加味当归贝母苦参丸汤剂辨证加减。比较2组患者肿瘤体积、生活质量评分、中医证候积分、免疫功能指标及不良反应。结果2组各有37例患者完成临床观察。3个疗程结束时，肿瘤客观反应率联合治疗组为91.9%，常规对照组为86.4%。2组患者治疗后临床症状(发热、呕吐、腹痛、乏力)均显著改善(P＜0.05)，联合治疗组优于常规对照组(P＜0.05)。联合治疗组治疗后卡氏评分升高(P＜0.05)，高于常规对照组(P＜0.05)。联合治疗组治疗后Th1功能水平升高(P＜0.05)，高于常规对照组(P＜0.05)。联合治疗组肝功能和消化道不良反应低于常规对照组(P＜0.05)。结论加味当归贝母苦参丸对化疗栓塞治疗原发性肝癌具有增效作用，并且能够减少不良反应，提高患者的生存质量。
목적：관찰가미당귀패모고삼환보조경간동맥화료전새술치료원발성간암적림상료효。방법장원발성간암환자84례수궤분위연합치료조화상규대조조각42례。상규대조조채용경간동맥화료전새술치료，연합치료조재차기출상급여가미당귀패모고삼환탕제변증가감。비교2조환자종류체적、생활질량평분、중의증후적분、면역공능지표급불량반응。결과2조각유37례환자완성림상관찰。3개료정결속시，종류객관반응솔연합치료조위91.9%，상규대조조위86.4%。2조환자치료후림상증상(발열、구토、복통、핍력)균현저개선(P＜0.05)，연합치료조우우상규대조조(P＜0.05)。연합치료조치료후잡씨평분승고(P＜0.05)，고우상규대조조(P＜0.05)。연합치료조치료후Th1공능수평승고(P＜0.05)，고우상규대조조(P＜0.05)。연합치료조간공능화소화도불량반응저우상규대조조(P＜0.05)。결론가미당귀패모고삼환대화료전새치료원발성간암구유증효작용，병차능구감소불량반응，제고환자적생존질량。
Objective To evaluate the clinical efficacy of modified Angelica Fritilaria Sophorae Pill assisting transcatheter arterial chemoembolization (TACE) to treat primary liver cancer. Methods Totally 84 patients with primary liver cancer were randomized into combination treatment group (42 cases) and conventional control group (42 cases). The conventional control group received TACE treatment, the combination treatment group received modified Angelica Fritilaria Sophorae Decoction and TACE. The tumor volume, TCM syndrome score, life quality, immune function and toxicity reaction of both groups were observed. Results Clinical observation was completed with 37 patients in each group. After three courses of treatment, the objective tumor response rate was 91.9% in combination treatment group and 86.4% in conventional control group (P<0.05). The clinical symptoms (fever, abdominal pain, vomiting, fatigue) in both groups were improved (P<0.05), with significant difference between the two groups (P<0.05). After treatment, KPS scores increased (P<0.05) in combination treatment group, and the scores of combination treatment group were significantly higher than those of the conventional control group (P<0.05). After treatment, Th1 function level increased (P<0.05) in combination treatment group, and that was better than the conventional control group (P<0.05). The incidence of liver toxicity and gastrointestinal reaction in the combination treatment group was significantly lower than that in the conventional control group (P<0.05). Conclusion Modified Angelica Fritilaria Sophorae Pill can enhance the efficacy of TACE treatment to treat primary liver cancer, reduce adverse reactions, and improve life quality of patients with primary liver cancer.