CAJ | 학술논문

目的：观察MELD-Na（血清钠与终末期肝病模型联合公式）模型评分系统在终末期肝病短期预后的作用，评估血浆置换术在终末期肝病治疗中的疗效。方法选择90例终末期肝病患者随机分为观察组52例和对照组38例，对其进行MELD-Na评分，并对观察组进行血浆置换术后MELD-Na评分，观察3个月内死亡率。结果在PE（血浆置换术）治疗前后总胆红素和INR（国际标准化比值）、凝血酶原时间的变化差异有统计学意义（P＜0.05）；30<MELD-Na<50的患者经PE治疗后MELD-Na评分显著下降，差异有统计学意义（P＜0.05），MELD-Na≥50的患者经PE治疗后3个月时病死率均为100%。结论血浆置换治疗能有效改善肝衰竭患者生化指标和MELD-Na评分。
목적：관찰MELD-Na（혈청납여종말기간병모형연합공식）모형평분계통재종말기간병단기예후적작용，평고혈장치환술재종말기간병치료중적료효。방법선택90례종말기간병환자수궤분위관찰조52례화대조조38례，대기진행MELD-Na평분，병대관찰조진행혈장치환술후MELD-Na평분，관찰3개월내사망솔。결과재PE（혈장치환술）치료전후총담홍소화INR（국제표준화비치）、응혈매원시간적변화차이유통계학의의（P＜0.05）；30<MELD-Na<50적환자경PE치료후MELD-Na평분현저하강，차이유통계학의의（P＜0.05），MELD-Na≥50적환자경PE치료후3개월시병사솔균위100%。결론혈장치환치료능유효개선간쇠갈환자생화지표화MELD-Na평분。
Objective To observe the practical use of the end-stage liver disease MELD-Na scoring system on clinic and ther ole of plasma exchange on end-stage liver disease.Methods 90 patients were divided ra ndomly into observation group and control group, and they were graded with MELD-Na bef o re and after plasma exchange.The death rate are observed three months later.Results There were obvious exchanges of total serum bilirubin,INR and prothrombin ti me in the 52 patients with liver failure before and after PE(P<0.05); the i m provement was found in patients with score less at 30 to 50(P<0.05); 12 ca s es with score higher than 50 were all dead.Conclusion Plasma exchange can s ignificantly improve clinical outcomes of patients with liver failure,especially inthose at early to middle stage disease.