CAJ | 학술논문

目的：分析研究视网膜黄斑区神经节复合体（ GCC）的厚度与眼轴长度的相关关系，以期指导临床应用。方法前瞻性病例分析研究。选取2014年5月至2014年10月期间在山东省眼科医院屈光中心就诊的患者连续性病例共93例（184只眼）。根据眼轴长度分为A组（眼轴22～24 mm），15例（29只眼）；B组（眼轴＞24～26 mm），50例（100只眼）；C组（眼轴＞26 mm），28例（55只眼）。眼部检查指标包括：眼轴长度、平均GCC厚度（ Avg．GCC）、上方GCC厚度（ Sup．GCC）、下方GCC厚度（ Ing．GCC）、局部丢失容积（ FLV）及总体丢失容积（ GLV）。分析3组间GCC厚度的差异及眼轴长度与GCC厚度的相关关系。对数据进行单因素方差分析和Pear-son相关性分析。结果3组受试者眼轴长度分别为A组（23．31±0．53） mm，B组（25．20±0．49） mm，C组（26．91±0．99）mm；A组、B组、C组Avg．GCC分别为（97．19±5．09）μm、（92．74±5．50）μm、（92．84±5．74）μm，3组比较差异有统计学意义（ P ＝0．001）；3组Sup．GCC与Ing．GCC 分别为（97．56±5．06）μm、（93．37±6．18）μm、（93．22±5．99）μm （ P ＝0．002）和（96．83±5．51）μm、（92．11±5．80）μm、（92．47±5．96）μm （ P ＝0．001），3组间比较二者差异均有统计学意义；GLV分别为（5．56±4．19）％、（8．28±5．46）％、（8．61±5．13）％，3组间比较差异有统计学意义（ P ＝0．026）。此外，3组间FLV（％）比较无统计学意义（ F ＝0．659， P ＝0．518）。 Pearson分析结果显示：GCC厚度值参数与眼轴长度呈显著负相关（ P ＜0．05）。结论 GCC厚度与眼轴长度呈负相关，随着眼轴变长，GCC厚度逐渐变薄。
목적：분석연구시망막황반구신경절복합체（ GCC）적후도여안축장도적상관관계，이기지도림상응용。방법전첨성병례분석연구。선취2014년5월지2014년10월기간재산동성안과의원굴광중심취진적환자련속성병례공93례（184지안）。근거안축장도분위A조（안축22～24 mm），15례（29지안）；B조（안축＞24～26 mm），50례（100지안）；C조（안축＞26 mm），28례（55지안）。안부검사지표포괄：안축장도、평균GCC후도（ Avg．GCC）、상방GCC후도（ Sup．GCC）、하방GCC후도（ Ing．GCC）、국부주실용적（ FLV）급총체주실용적（ GLV）。분석3조간GCC후도적차이급안축장도여GCC후도적상관관계。대수거진행단인소방차분석화Pear-son상관성분석。결과3조수시자안축장도분별위A조（23．31±0．53） mm，B조（25．20±0．49） mm，C조（26．91±0．99）mm；A조、B조、C조Avg．GCC분별위（97．19±5．09）μm、（92．74±5．50）μm、（92．84±5．74）μm，3조비교차이유통계학의의（ P ＝0．001）；3조Sup．GCC여Ing．GCC 분별위（97．56±5．06）μm、（93．37±6．18）μm、（93．22±5．99）μm （ P ＝0．002）화（96．83±5．51）μm、（92．11±5．80）μm、（92．47±5．96）μm （ P ＝0．001），3조간비교이자차이균유통계학의의；GLV분별위（5．56±4．19）％、（8．28±5．46）％、（8．61±5．13）％，3조간비교차이유통계학의의（ P ＝0．026）。차외，3조간FLV（％）비교무통계학의의（ F ＝0．659， P ＝0．518）。 Pearson분석결과현시：GCC후도치삼수여안축장도정현저부상관（ P ＜0．05）。결론 GCC후도여안축장도정부상관，수착안축변장，GCC후도축점변박。
Objective To observe and analysis the correlation between macular ganglion cell complex thickness and ocular axial length in order to guide the clinical work.Methods This was a prospective study.We reviewed 93 sec-ondary keratoconus patients (184 eyes) who were diagnosed and treated in Shandong Eye Hospital Refractive Center be-tween 2014 May to December.All patients were divided into group A (22~24 mm), group B (24~26 mm) and group C (>26 mm) according to the ocular axis length.Fifteen subjects (29 eyes) were in group A, 50 subjects (100 eyes) in group B, and 28 subjects (55 eyes) were in group C.The ocular examination included ocular axis length, average thick-ness of GCC ( Avg GCC) , superior thickness of GCC ( Sup GCC) , inferior thickness of GCC ( Ing GCC) , focal loss of vol-ume ( FLV) and general loss of volume ( GLV) .We analyzed the difference of GCC thickness among three groups and ob-served the correlation between the ocular axis length and the GCC thickness.The collected data were analyzed with One-way ANOVA and Person correlation.Results Mean ocular axis length were 23.31 ±0.53 mm in group A, 25.20 ±0.49 mm in group B, and 26.91 ±0.99mm in group C.The Avg GCC values were 97.19 ±5.09 μm, 92.74 ±5.50 μm, and 92.84 ±5.74 μm, respectively.The differences were statistically significant ( P =0.001).The Sup GCC values were 97.56 ±5.06 μm, 93.37 ±6.18 μm, and 93.22 ±5.99 μm respectively, and Ing GCC values were 96.83 ±5.51 μm, 92.11 ±5.80 μm, and 92.47 ±5.96 μm, respectively.And the differences in Sup GCC and Ing GCC were statistically significant ( P =0.002 and P =0.001).The GLV were 5.56 ±4.19%, 8.28 ±5.46%, and 8.61 ±5.13% ( P =0.026).However, the FLV showed no significant difference among the three groups ( F =0.659, P =0.518).The result of Pearson Analysis indicated that the thickness of GCC was negatively correlated to the ocular axis length ( P <0.05). Conclusion The thickness of GCC was negatively correlated to the ocular axis length.