CAJ | 학술논문

目的：观察分析透明质酸（HA）与骨形态发生蛋白（BMP）在非小细胞肺癌骨转移中的应用价值。方法随机选取我院收治的59例非小细胞肺癌骨转移患者，同时选取60例非小细胞肺癌患者作为对照组，通过γ免疫计数器放射免疫方法检测HA和BMP通过放射免疫方法检测，骨转移的诊断及随访通过SPECT以及其他影像方法或随访获得。结果非小细胞肺癌骨转移患者血清HA＞48 ng/ml（97%）明显高于对照组非小细胞肺癌未发生骨转移患者（8%），差异有统计学意义（P＜0．05）；非小细胞肺癌骨转移患者血清BMP2、4、5、6检测值均明显高于对照组非小细胞肺癌未发生骨转移患者BMP2、4、5、6检测值，差异有统计学意义（P＜0．05）。结论HA及BMP预测非小细胞肺癌骨转移患者预后效果，方法较为简单，前期投入并不昂贵，患者检测的成本较低，适用于广大基层医院对非小细胞肺癌患者骨转移的诊治和监测的工作，具有推广和应用价值。
목적：관찰분석투명질산（HA）여골형태발생단백（BMP）재비소세포폐암골전이중적응용개치。방법수궤선취아원수치적59례비소세포폐암골전이환자，동시선취60례비소세포폐암환자작위대조조，통과γ면역계수기방사면역방법검측HA화BMP통과방사면역방법검측，골전이적진단급수방통과SPECT이급기타영상방법혹수방획득。결과비소세포폐암골전이환자혈청HA＞48 ng/ml（97%）명현고우대조조비소세포폐암미발생골전이환자（8%），차이유통계학의의（P＜0．05）；비소세포폐암골전이환자혈청BMP2、4、5、6검측치균명현고우대조조비소세포폐암미발생골전이환자BMP2、4、5、6검측치，차이유통계학의의（P＜0．05）。결론HA급BMP예측비소세포폐암골전이환자예후효과，방법교위간단，전기투입병불앙귀，환자검측적성본교저，괄용우엄대기층의원대비소세포폐암환자골전이적진치화감측적공작，구유추엄화응용개치。
Objective To observe the application value of hyaluronic acid and bone morphogenetic protein in non small cell lung cancer with bone metastasis. Methods Fifty-nine cases of non small cell lung cancer patients with bone metastasis were randomly choose, and selected 60 cases of non small cell lung cancer patients as control group, by detecting the gamma immune counter radioimmunoassay hyaluronic acid and bone morphogenetic protein by radioimmunoassay, diagnosis and follow-up of bone metastases were obtained through SPECT and other image method or follow-up. Results Non small cell lung cancer patients with bone metastases serum of two groups of patients with serum HA>48 ng/ml (97%) was significantly higher than the control group of non small cell lung cancer patients with bone metastasis has not occurred (8%), statistically significant (P<0.05); serum of patients with non-small cell lung cancer with bone metastasis in patients with serum BMP2,4,5,6 detected values were significantly higher in both groups of non-small cell lung cancer patients with bone metastasis detection value BMP2,4,5,6 did not occur, there is a statistically significance (P<0.05). Conclusion hyaluronic acid and bone formation non-small cell lung cancer pa-tients with bone metastasis prognosis, the method is simple, inexpensive initial investment, low cost detection of pa-tients suitable for the majority of patients with bone protein primary hospital forecast for non-small cell lung cancer di-agnosis, treatment and monitoring of the work shift, with the promotion and application value.