CAJ | 학술논문

目的：观察非动脉炎性前部缺血性视神经病变（ NAION）的危险因素，为该病提供防治措施。方法对我院2009年至2013年5年间住院的并确诊为NAION的患者和同期体健中心的体检人群的实验室检查、24 h血压、全身及一般情况、眼部检查等进行分析，籍以说明其患病的危险因素，深入研究各种因素与该病的相互关系及特点，并通过临床干预性治疗，显现出该研究对此类疾病预后的影响。结果病例组发病年龄（57．89±10．32）岁，男性占47．84％，女性占52．16％。病例组中高血压、高血糖、胆固醇、甘油三酯、红细胞压积偏低及颈动脉超声异常的比例分别是49．07％、33．02％、23．53％、29．9％、8．25％及59．73％。对照组年龄（54．02±11．85）岁，男性占57.58％，女性占42．42％，高血压、高血糖、胆固醇、甘油三酯、红细胞压积偏低及颈动脉超声异常比例分别是23.64％、10％、16．97％、27．87％、7．57％及41．05％。结论病例组高血压、高血糖、高血脂、红细胞压积偏低、颈动脉超声异常及夜间低血压发病率明显高于对照组。且病例组发病年龄有年轻化的趋势，男性略高于女性，高血压、高血糖、血脂、颈动脉异常及夜间低血压等是主要的危险因素。对于NAION的患者应积极查找全身病因，并给予有效干预。对高危人群和已患病人群做出高发病例、治疗预后等情况做出科学的评估。
목적：관찰비동맥염성전부결혈성시신경병변（ NAION）적위험인소，위해병제공방치조시。방법대아원2009년지2013년5년간주원적병학진위NAION적환자화동기체건중심적체검인군적실험실검사、24 h혈압、전신급일반정황、안부검사등진행분석，적이설명기환병적위험인소，심입연구각충인소여해병적상호관계급특점，병통과림상간예성치료，현현출해연구대차류질병예후적영향。결과병례조발병년령（57．89±10．32）세，남성점47．84％，녀성점52．16％。병례조중고혈압、고혈당、담고순、감유삼지、홍세포압적편저급경동맥초성이상적비례분별시49．07％、33．02％、23．53％、29．9％、8．25％급59．73％。대조조년령（54．02±11．85）세，남성점57.58％，녀성점42．42％，고혈압、고혈당、담고순、감유삼지、홍세포압적편저급경동맥초성이상비례분별시23.64％、10％、16．97％、27．87％、7．57％급41．05％。결론병례조고혈압、고혈당、고혈지、홍세포압적편저、경동맥초성이상급야간저혈압발병솔명현고우대조조。차병례조발병년령유년경화적추세，남성략고우녀성，고혈압、고혈당、혈지、경동맥이상급야간저혈압등시주요적위험인소。대우NAION적환자응적겁사조전신병인，병급여유효간예。대고위인군화이환병인군주출고발병례、치료예후등정황주출과학적평고。
Objective To investigate the risk factors of non-arteritic anterior ischemic optic neuropathy ( NAION) , and to provide the guidance for proper prevention and treatment.Methods Ahthor examined patients that were diagnosed with NAION and were treated in our hospital between 2009 to 2013.Medical and ophthalmic records, 24-hour blood pressure, and other laboratory tests were reviewed and compared to those of time-matched normal population, in order to find out the risk factors of the disease and its characteristic manifestations, and to optimize the treatments.Results Av-erage age of the patients was 57.89 ±10.32.There were 47.84%males and 52.16%females.Comorbidities are common among NAION patients, including hypertension (49.07%), hyperglycemia (33.02%), hypercholesteremia (23.53%), hypertriglyceridemia (29.90%), low hematocrit (8.25%), and abnormal carotid artery ultrasonography (59.73%).In contrast, these comorbidities were less common in normal population.Conclusion Systemic comorbidities are more com-mon in NAION patients, and more common in men than in women.Major risk factors include hypertension, hyperglycemia, dyslipidemia, abnormal carotid artery ultrasonography, and nocturnal hypotension.Therefore it is important to identify and treat these risk factors in NAION patients and to prevent NAION.