中国循证心血管医学杂志
中國循證心血管醫學雜誌
중국순증심혈관의학잡지
CHINESE JOURNAL OF EVIDENCE-BASES CARDIOVASCULAR MEDICINE
2015年
2期
188-191
,共4页
邹青%赵连友%李雪%徐希平%王滨燕%卫聪颖%王继鹏%鲁轩浩%张志敏%丁璐%王增强
鄒青%趙連友%李雪%徐希平%王濱燕%衛聰穎%王繼鵬%魯軒浩%張誌敏%丁璐%王增彊
추청%조련우%리설%서희평%왕빈연%위총영%왕계붕%로헌호%장지민%정로%왕증강
依那普利叶酸片%H型高血压%左室肥厚%心功能%同型半胱氨酸
依那普利葉痠片%H型高血壓%左室肥厚%心功能%同型半胱氨痠
의나보리협산편%H형고혈압%좌실비후%심공능%동형반광안산
Enalapril maleate and folic acid tablets%H-type hypertension%Left ventricular hypertrophy%Heart function%Homocysteine
目的：观察依那普利叶酸片改善H型高血压左室肥厚患者心功能的作用。方法纳入160例H型高血压左室肥厚患者，随机分为依那普利组（n=80）和依那普利叶酸片组（依叶组）。治疗12个月后，观察两组患者血压、心功能及血浆同型半胱氨酸（Hcy）水平的变化。结果①两组患者治疗后收缩压（SBP）、舒张压（DBP）与治疗前比较，均有非常显著性降低（P＜0.01），治疗后两组患者间SBP、DBP比较均有统计学差异（P均＜0.05），且依叶组降血压效果更明显。②治疗后，依叶组患者血浆Hcy水平与治疗前相比显著降低（P＜0.01），依那普利组患者血浆Hcy水平与治疗前相比有明显降低（P＜0.05）；两组患者治疗后血浆Hcy水平比较有显著统计学差异（P＜0.01），且依叶组血浆Hcy水平降低更明显。③两组患者治疗后左室舒张早期二尖瓣血流峰速度（E）及晚期血流峰速度（A）比值（E/A）及左室射血分数（LVEF）值与治疗前比较均显著升高（P＜0.01），治疗后两组患者间E/A值、LVEF值比较均有统计学差异（P＜0.05），且依叶组升高效果更明显。结论依那普利叶酸片能更好的降低H型高血压左室肥厚患者血压及血浆Hcy水平，改善左室的舒张及收缩功能。
目的：觀察依那普利葉痠片改善H型高血壓左室肥厚患者心功能的作用。方法納入160例H型高血壓左室肥厚患者，隨機分為依那普利組（n=80）和依那普利葉痠片組（依葉組）。治療12箇月後，觀察兩組患者血壓、心功能及血漿同型半胱氨痠（Hcy）水平的變化。結果①兩組患者治療後收縮壓（SBP）、舒張壓（DBP）與治療前比較，均有非常顯著性降低（P＜0.01），治療後兩組患者間SBP、DBP比較均有統計學差異（P均＜0.05），且依葉組降血壓效果更明顯。②治療後，依葉組患者血漿Hcy水平與治療前相比顯著降低（P＜0.01），依那普利組患者血漿Hcy水平與治療前相比有明顯降低（P＜0.05）；兩組患者治療後血漿Hcy水平比較有顯著統計學差異（P＜0.01），且依葉組血漿Hcy水平降低更明顯。③兩組患者治療後左室舒張早期二尖瓣血流峰速度（E）及晚期血流峰速度（A）比值（E/A）及左室射血分數（LVEF）值與治療前比較均顯著升高（P＜0.01），治療後兩組患者間E/A值、LVEF值比較均有統計學差異（P＜0.05），且依葉組升高效果更明顯。結論依那普利葉痠片能更好的降低H型高血壓左室肥厚患者血壓及血漿Hcy水平，改善左室的舒張及收縮功能。
목적：관찰의나보리협산편개선H형고혈압좌실비후환자심공능적작용。방법납입160례H형고혈압좌실비후환자，수궤분위의나보리조（n=80）화의나보리협산편조（의협조）。치료12개월후，관찰량조환자혈압、심공능급혈장동형반광안산（Hcy）수평적변화。결과①량조환자치료후수축압（SBP）、서장압（DBP）여치료전비교，균유비상현저성강저（P＜0.01），치료후량조환자간SBP、DBP비교균유통계학차이（P균＜0.05），차의협조강혈압효과경명현。②치료후，의협조환자혈장Hcy수평여치료전상비현저강저（P＜0.01），의나보리조환자혈장Hcy수평여치료전상비유명현강저（P＜0.05）；량조환자치료후혈장Hcy수평비교유현저통계학차이（P＜0.01），차의협조혈장Hcy수평강저경명현。③량조환자치료후좌실서장조기이첨판혈류봉속도（E）급만기혈류봉속도（A）비치（E/A）급좌실사혈분수（LVEF）치여치료전비교균현저승고（P＜0.01），치료후량조환자간E/A치、LVEF치비교균유통계학차이（P＜0.05），차의협조승고효과경명현。결론의나보리협산편능경호적강저H형고혈압좌실비후환자혈압급혈장Hcy수평，개선좌실적서장급수축공능。
Objective To observe the improving effect of enalapril maleate and folic acid tablets on heart function in patients with H-type hypertension and left ventricular hypertrophy (LVH).Methods The patients (n=160) were chosen and divided randomly into enalapril maleate group (EM group,n=80) and enalapril maleate and folic acid tablets group (EMFA group,n=80). After treatment for 12 m, the changes of blood pressure, heart function and level of plasma homocysteine (Hcy) were observed in 2 groups.Results ①SBP and DBP decreased significantly after treatment in 2 groups (P<0.01), and the comparisons in SBP or DBP had statistical differences between 2 groups after treatment (allP<0.05). Blood pressure decreased much significantly in EMFA group. ②After treatment, the level of plasma Hcy decreased significantly in EMFA group (P<0.01) and decreased in EM group (P<0.05), and the comparison in level of plasma Hcy had significantly statistical difference between 2 groups after treatment (P<0.01). The level of plasma Hcy decreased much significantly in EMFA group. ③The ratio of left ventricular peak early diastolic mitral flow velocity (E) and late peak flow velocity (A, E/A) and LVEF increased significantly in 2 groups after treatment (P<0.01). The comparisons in E/A and LVEF had statistical differences between 2 groups after treatment (P<0.05), which were more significant in EMFA group.Conclusion Enalapril maleate and folic acid tablets can reduce blood pressure and level of plasma Hcy and improve left ventricular diastolic and systolic functions in patients with H-type hypertension and LVH.
