CAJ | 학술논문

目的：评价冠心舒通胶囊对慢性稳定型心绞痛（心血瘀阻证）的双心疾病（心脏病及心理疾病）治疗效果。方法入选稳定型心绞痛住院或门诊患者134例，随机分为试验组（n=67）和对照组（n=65），对照组给予西医常规治疗，试验组在西医常规治疗基础上加用冠心舒通胶囊（3粒，tid）。随访观察4周，评价患者心绞痛和中医症候改善情况，治疗前后均采用焦虑自评量表（SAS）和抑郁自评量表（SDS）对患者进行焦虑和抑郁评定，同时记录患者药物不良反应情况。结果试验组较对照组患者心绞痛改善总有效率和中医症候改善总有效率明显提升（分别是83.6%vs.63.1%，P＜0.05；89.6%vs.72.3%，P＜0.05）。试验组较对照组明显降低患者焦虑和抑郁的发生率以及症状评分（SAS评分下降值：15.57±15.77vs.7.06±20.80，P＜0.05；SDS评分下降值：13.58±14.76vs.6.46±16.65，P＜0.05）。试验组较对照组胃肠道不适的不良反应增多（17.9%vs.6.0%，P＜0.05），两组均未发生胃肠道出血。结论冠心舒通胶囊治疗稳定型心绞痛（心血瘀阻证）疗效确切，亦可改善患者焦虑和抑郁障碍，发挥双心治疗效应，并且较为安全可靠。
목적：평개관심서통효낭대만성은정형심교통（심혈어조증）적쌍심질병（심장병급심리질병）치료효과。방법입선은정형심교통주원혹문진환자134례，수궤분위시험조（n=67）화대조조（n=65），대조조급여서의상규치료，시험조재서의상규치료기출상가용관심서통효낭（3립，tid）。수방관찰4주，평개환자심교통화중의증후개선정황，치료전후균채용초필자평량표（SAS）화억욱자평량표（SDS）대환자진행초필화억욱평정，동시기록환자약물불량반응정황。결과시험조교대조조환자심교통개선총유효솔화중의증후개선총유효솔명현제승（분별시83.6%vs.63.1%，P＜0.05；89.6%vs.72.3%，P＜0.05）。시험조교대조조명현강저환자초필화억욱적발생솔이급증상평분（SAS평분하강치：15.57±15.77vs.7.06±20.80，P＜0.05；SDS평분하강치：13.58±14.76vs.6.46±16.65，P＜0.05）。시험조교대조조위장도불괄적불량반응증다（17.9%vs.6.0%，P＜0.05），량조균미발생위장도출혈。결론관심서통효낭치료은정형심교통（심혈어조증）료효학절，역가개선환자초필화억욱장애，발휘쌍심치료효응，병차교위안전가고。
Objective To review the curative effect of Guanxin Shutong Capsules on psychocardiacology in patients with chronic stable angina pectoris (SAP, syndrome of heart blood stasis).Methods SAP patients (n=134) were chosen from wards or out-patient department, and randomly divided into test group (n=67) and control group (n=65). The control group was given routine therapy of Western medicine and test group was given Guanxin Shutong Capsules (3 capsules, tid) based on routine therapy of Western medicine. All patients were observed and followed up for 4 w. The amelioration of AP and TCM symptoms were reviewed in all groups. The patients were given anxiety and depression reviews by using self-rating anxiety scale (SAS) and self-rating depressive scale (SDS) before and after treatment, and adverse reactions were recorded.Results The total effective rate of AP amelioration and that of TCM symptom amelioration were significantly improved in test group compared with control group (83.6%vs. 63.1%,P<0.05; 89.6%vs. 72.3%,P<0.05). The incidence of anxiety or depression and symptom scores decreased significantly in test group compared with control group (SAS decrease value: 15.57±15.77vs. 7.06± 20.80,P<0.05; SDS decrease value: 13.58±14.76vs. 6.46±16.65,P<0.05). The gastrointestinal adverse reactions increased in test group compared with control group (17.9%vs. 6.0%,P<0.05), and there was no gastrointestinal bleeding observed in 2 groups.Conclusion Guanxin Shutong Capsules has reliable curative effect on SAP (syndrome of heart blood stasis), which at the same time can ameliorate anxiety and depression symptoms and play a role of treating psychocardiacology with higher safety.