CAJ | 학술논문

目的：探讨男性急性冠状动脉综合征患者性激素睾酮水平、血脂及高敏C反应蛋白（hs-CRP）的相关性。方法连续收集2012年3月~10月于上海市第五人民医院心内科因胸闷、胸痛住院的男性患者共284例，年龄50~80岁。根据冠状动脉（冠脉）造影结果分为急性冠脉综合征组（97例）和稳定性心绞痛组（105例），非冠心病组（82例）。根据冠状动脉造影结果分为三支病变、两支病变、单支病变。检测所有患者血脂、性激素睾酮和hs-CRP水平。并分析各检测指标间的相关性。结果与急性冠脉综合征组比较，稳定性心绞痛组睾酮和三酰甘油（TG）水平升高，差异有统计学意义（P均＜0.05）， hs-CRP降低，差异有显著统计学意义（P＜0.01）。与急性冠脉综合征组比较，非冠心病组睾酮和TG升高，hs-CRP降低，有显著统计学差异（P均＜0.01）。非冠心病组较稳定性心绞痛组总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）以及睾酮水平升高，hs-CRP降低，差异有统计学意义（P均＜0.05）。男性冠心病睾酮与血脂、hs-CRP水平无明显相关（P均＞0.05）。单支病变、双支病变以及三支病变睾酮水平无统计学差异（P均＞0.05）。结论男性急性冠脉综合症患者睾酮水平下降、hs-CRP升高，未发现睾酮与血脂、hs-CRP相关，不同冠状动脉病变程度睾酮水平亦无统计学差异。
목적：탐토남성급성관상동맥종합정환자성격소고동수평、혈지급고민C반응단백（hs-CRP）적상관성。방법련속수집2012년3월~10월우상해시제오인민의원심내과인흉민、흉통주원적남성환자공284례，년령50~80세。근거관상동맥（관맥）조영결과분위급성관맥종합정조（97례）화은정성심교통조（105례），비관심병조（82례）。근거관상동맥조영결과분위삼지병변、량지병변、단지병변。검측소유환자혈지、성격소고동화hs-CRP수평。병분석각검측지표간적상관성。결과여급성관맥종합정조비교，은정성심교통조고동화삼선감유（TG）수평승고，차이유통계학의의（P균＜0.05）， hs-CRP강저，차이유현저통계학의의（P＜0.01）。여급성관맥종합정조비교，비관심병조고동화TG승고，hs-CRP강저，유현저통계학차이（P균＜0.01）。비관심병조교은정성심교통조총담고순（TC）、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL-C）이급고동수평승고，hs-CRP강저，차이유통계학의의（P균＜0.05）。남성관심병고동여혈지、hs-CRP수평무명현상관（P균＞0.05）。단지병변、쌍지병변이급삼지병변고동수평무통계학차이（P균＞0.05）。결론남성급성관맥종합증환자고동수평하강、hs-CRP승고，미발현고동여혈지、hs-CRP상관，불동관상동맥병변정도고동수평역무통계학차이。
Objective To investigate the correlation among sex hormones, blood fat and high-sensitivity C-reactive protein (hs-CRP) in male patients with acute coronary syndrome (ACS).Methods Male patients (n=284, aged from 50 to 80) hospitalized due to chest oppression and chest pain were chosen from Mar. 2012 to Oct. 2012. All patients were divided, according to outcomes of coronary angiography (CAG), into acute coronary syndrome group (ACS group,n=97), stable angina pectoris group (SAP group,n=105) and non-CHD group (n=82). The outcomes of CAG showed that coronary artery lesion included 3-vessel lesion, 2-vessel lesion and 1-vessel lesion. The levels of blood fat, testosterone and hs-CRP were detected and correlation among these indexes was analyzed.Results The levels of testosterone and triglyceride (TG) increased (allP<0.05), and hs-CRP level decreased (P<0.01) in SAP group compared with ACS group. The levels of testosterone and TG increased and hs-CRP level decreased in non-CHD group compared with ACS group (allP<0.01). The levels of total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) and testosterone increased, and hs-CRP level decreased in non-CHD group compared with SAP group (allP<0.05). The level of testosterone was not correlated to levels of blood fat and hs-CRP (allP>0.05). The level of testosterone had no statistical difference in patients with 1-vessel lesion, 2-vessel lesion or 3-vessel lesion (allP>0.05).Conclusion The level of testosterone decreases and hs-CRP level increases in male patients with ACS. The correlation has not been found among testosterone, blood fat and hs-CRP. There is no statistical difference in patients with different severity of coronary lesion.