中国继续医学教育
中國繼續醫學教育
중국계속의학교육
CHINA CONTINUING MEDICAL EDUCATION
2015年
8期
14-15
,共2页
人乳头瘤病毒%亚型分布%筛查
人乳頭瘤病毒%亞型分佈%篩查
인유두류병독%아형분포%사사
Human papillomavirous%Genotype distribution%Screening
目的：调查天津市妇女宫颈人乳头瘤病毒（HPV）感染现状和基因各亚型分布情况，为研究宫颈癌疫苗和防治宫颈癌提供依据。方法采用聚合酶链式反应（Polymerase Chain Reaction，PCR）反向点杂交基因芯片技术对6132名做宫颈癌筛查的女性宫颈脱落细胞标本进行HPV基因分型检测，分析HPV在女性人群中的感染率、基因型别和年龄分布特点。结果6132例标本中HPV阳性例数为1296例，总感染率为21.14%。共检测出23种基因亚型，其中高危型18种、低危型5种。高危型HPV52及16感染率最高，分别为11.46%和10.85%，高危型出现次数的排序：52＞16＞58＞53＞51；低危型HPV6感染率最高，其次为HPV43。20～29岁及30～39岁组感染率远高于其他年龄组，差异有统计学意义。结论天津市妇女HPV52、16型感染最常见，年轻妇女HPV感染率最高，HPV分型检测在宫颈癌的早期预防、早期诊断具有重要意义。
目的：調查天津市婦女宮頸人乳頭瘤病毒（HPV）感染現狀和基因各亞型分佈情況，為研究宮頸癌疫苗和防治宮頸癌提供依據。方法採用聚閤酶鏈式反應（Polymerase Chain Reaction，PCR）反嚮點雜交基因芯片技術對6132名做宮頸癌篩查的女性宮頸脫落細胞標本進行HPV基因分型檢測，分析HPV在女性人群中的感染率、基因型彆和年齡分佈特點。結果6132例標本中HPV暘性例數為1296例，總感染率為21.14%。共檢測齣23種基因亞型，其中高危型18種、低危型5種。高危型HPV52及16感染率最高，分彆為11.46%和10.85%，高危型齣現次數的排序：52＞16＞58＞53＞51；低危型HPV6感染率最高，其次為HPV43。20～29歲及30～39歲組感染率遠高于其他年齡組，差異有統計學意義。結論天津市婦女HPV52、16型感染最常見，年輕婦女HPV感染率最高，HPV分型檢測在宮頸癌的早期預防、早期診斷具有重要意義。
목적：조사천진시부녀궁경인유두류병독（HPV）감염현상화기인각아형분포정황，위연구궁경암역묘화방치궁경암제공의거。방법채용취합매련식반응（Polymerase Chain Reaction，PCR）반향점잡교기인심편기술대6132명주궁경암사사적녀성궁경탈락세포표본진행HPV기인분형검측，분석HPV재녀성인군중적감염솔、기인형별화년령분포특점。결과6132례표본중HPV양성례수위1296례，총감염솔위21.14%。공검측출23충기인아형，기중고위형18충、저위형5충。고위형HPV52급16감염솔최고，분별위11.46%화10.85%，고위형출현차수적배서：52＞16＞58＞53＞51；저위형HPV6감염솔최고，기차위HPV43。20～29세급30～39세조감염솔원고우기타년령조，차이유통계학의의。결론천진시부녀HPV52、16형감염최상견，년경부녀HPV감염솔최고，HPV분형검측재궁경암적조기예방、조기진단구유중요의의。
Objective To provide theoretical basis for the development of vaccine and the treatment of cervical cancer, the status of human papillomavirus (HPV) in cervical cells of Tianjin women was investigated. Methods HPV genotype in 6 132 screening women was detected by human papillomavirus polymerase chain reaction (PCR) types diagnostic kit. The infection rate, genotype and age distribution in the female were analyzed. ResultsThe HPV infection women was 1 296 in screening 6 132 cases and the total infection rate was 21.14%. 23 genotypes were found. 18 kinds of the high risk and 5 kinds of low risk HPV genotypes were detected. The top risk genotypes were HPV52 and HPV16, and their infection rates were 11.46% and 10.85%, respectively. The infection rate of high risk HPV sorted as HPV52>16>58>53>51. The infection rate of HPV6 was highest in the low risk genotypes and was in the second rate for HPV43. The infection rate of 20~29 and 30~39 groups was much higher than that of the other groups. The difference was statistically signiifcant. ConclusionHPV52 and HPV16 were the major subtypes in the women of Tianjin. The infection rate of young women was higher than that of the other age groups. The detection of HPV genotypes is very meaningful in early prevention and diagnosis of cervical cancer.
