CAJ | 학술논문

目的：评估慢性阻塞性肺疾病( COPD)患者诱导痰及血清超敏C反应蛋白( hsCRP)的水平以及二者比值与其肺功能严重程度之间的相关性。方法连续收集2011年7月至2012年7月我院随访的稳定期COPD患者30例为研究对象,同时以30例健康志愿者为对照组,分别进行肺通气功能检查,采集诱导痰和空腹静脉血。测定诱导痰上清液和血清中hsCRP和IL-8的水平,评估他们与肺通气功能的相关性。结果 COPD稳定期患者诱导痰中hsCRP及IL-8水平均明显高于对照组(P<0．01)；且COPD患者诱导痰与血清中IL-8的比值以及诱导痰与血清中hsCRP的比值亦明显高于对照组(P<0．01)。 COPD稳定期患者诱导痰中hsCRP及IL-8水平,诱导痰及血清中IL-8及hsCRP的比值与患者气流受限的水平(FEV1/FVC)呈负相关(r值分别为-0．482,-0．477,-0．461,-0．524)。结论稳定期COPD患者体内存在着与气流受限呈负相关的IL-8及hsCRP增高的气道炎症,且炎症反应在气道的表达较COPD的系统性炎症更为明显。
목적：평고만성조새성폐질병( COPD)환자유도담급혈청초민C반응단백( hsCRP)적수평이급이자비치여기폐공능엄중정도지간적상관성。방법련속수집2011년7월지2012년7월아원수방적은정기COPD환자30례위연구대상,동시이30례건강지원자위대조조,분별진행폐통기공능검사,채집유도담화공복정맥혈。측정유도담상청액화혈청중hsCRP화IL-8적수평,평고타문여폐통기공능적상관성。결과 COPD은정기환자유도담중hsCRP급IL-8수평균명현고우대조조(P<0．01)；차COPD환자유도담여혈청중IL-8적비치이급유도담여혈청중hsCRP적비치역명현고우대조조(P<0．01)。 COPD은정기환자유도담중hsCRP급IL-8수평,유도담급혈청중IL-8급hsCRP적비치여환자기류수한적수평(FEV1/FVC)정부상관(r치분별위-0．482,-0．477,-0．461,-0．524)。결론은정기COPD환자체내존재착여기류수한정부상관적IL-8급hsCRP증고적기도염증,차염증반응재기도적표체교COPD적계통성염증경위명현。
Objective To investigate the concentration of hypersensitive C responsive protein( hsCRP) in inducing spu-tum and serum of COPD and the ration of hsCRP in inducing sputum and serum. To explore the correlation of the concentration of hsCRP in inducing sputum and serum and the ratio of the hsCRP in inducing sputum and serum with the disease severity by lung function test. Methods Tirty stable COPD patients and thirty healthy people from the outpatient department of institute of respira-tory disease of the 1 st affiliated hospital of China Medical University were collected as the subjective from June 2011 to June 2012. The serum and inducing sputum were gathered and the concentration of IL-8 and hsCRP in serum and inducing sputum was detec-ted,which were compared with the ventilation function from lung function test. Results The concentration of hsCRP and IL-8 in the inducing sputum of COPD patients was significantly higher than that of healthy group(P<0. 01). The ratio of IL-8 and hsCRP in inducing sputum to the IL-8 and hsCRP in serum was also significantly higher than that of healthy group(P<0. 01). The con-centration of IL-8 and hsCRP in inducing sputum,the ratio of IL-8 in inducing sputum to IL-8 in serum and ratio of hsCRP in indu-cing sputum to hsCRP in serum correlated negatively with FEV1/FVC(r= -0. 482,-0. 477,-0. 461,-0. 524). Conclusion Stable COPD presents with airway inflammation with increased IL-8 and hsCRP in airway which correlates with airflow limitation negatively;the airway inflammation manifests more significant than the systemic inflammation in COPD.