中国循证心血管医学杂志
中國循證心血管醫學雜誌
중국순증심혈관의학잡지
CHINESE JOURNAL OF EVIDENCE-BASES CARDIOVASCULAR MEDICINE
2015年
2期
211-214,224
,共5页
马度芳%姚晓东%庄欣%吴波%王燕%李晓
馬度芳%姚曉東%莊訢%吳波%王燕%李曉
마도방%요효동%장흔%오파%왕연%리효
不稳定心绞痛%心率变异性%超敏C反应蛋白%白介素6%相关性分析
不穩定心絞痛%心率變異性%超敏C反應蛋白%白介素6%相關性分析
불은정심교통%심솔변이성%초민C반응단백%백개소6%상관성분석
Unstable angina pectoris%Heart rate variability%High sensitivity C-reactive protein%Interleukin-6%Correlation analysis
目的:研究不稳定心绞痛(UA)患者炎性标志物与心率变异性之间的关系。方法自2013年6月至2014年6月在山东中医药大学附属医院心内科住院的UA患者40例,女性26例,男性14例,年龄50~80岁。将研究对象分为hs-CRP<1.0组 mg/L(n=15),hs-CRP(1.0~3.0)mg/L组(n=16), hs-CRP>3.0 mg/L组(n=9)。所有患者进行24 h动态心电图检测获取心率变异性(HRV),计算时域指标及频域指标。同时检测炎症因子超敏C反应蛋白(hs-CRP)和白介素-6(IL-6)含量。分析hs-CRP、IL-6的自然对数与SDNN、RMSSD的关系。结果 hs-CRP(>3 mg/L)组较hs-CRP(1~3 mg/L)组SDNN和RMSSD均降低,差异有统计学意义(P均<0.05)。各组间频域指标比较,随hs-CRP的升高,其低频(LF)、高频(HF)、极低频(VLF)和总功率(TP)逐渐降低,但各组间差异无统计学意义(P均>0.05)。单因素相关分析显示hs-CRP自然对数(Lnhs-CRP)与SDNN之间存在负相关性(r=-0.365,P=0.022),而Lnhs-CRP与RMSSD之间无明显相关。IL-6自然对数(LnIL-6)与SDNN呈负相关(r=-0.700,P<0.001),与RMSSD呈负相关(r=-0.457,P=0.003)。结论 UA患者HRV的降低与体内炎性标记物hs-CRP、IL-6增加相关。
目的:研究不穩定心絞痛(UA)患者炎性標誌物與心率變異性之間的關繫。方法自2013年6月至2014年6月在山東中醫藥大學附屬醫院心內科住院的UA患者40例,女性26例,男性14例,年齡50~80歲。將研究對象分為hs-CRP<1.0組 mg/L(n=15),hs-CRP(1.0~3.0)mg/L組(n=16), hs-CRP>3.0 mg/L組(n=9)。所有患者進行24 h動態心電圖檢測穫取心率變異性(HRV),計算時域指標及頻域指標。同時檢測炎癥因子超敏C反應蛋白(hs-CRP)和白介素-6(IL-6)含量。分析hs-CRP、IL-6的自然對數與SDNN、RMSSD的關繫。結果 hs-CRP(>3 mg/L)組較hs-CRP(1~3 mg/L)組SDNN和RMSSD均降低,差異有統計學意義(P均<0.05)。各組間頻域指標比較,隨hs-CRP的升高,其低頻(LF)、高頻(HF)、極低頻(VLF)和總功率(TP)逐漸降低,但各組間差異無統計學意義(P均>0.05)。單因素相關分析顯示hs-CRP自然對數(Lnhs-CRP)與SDNN之間存在負相關性(r=-0.365,P=0.022),而Lnhs-CRP與RMSSD之間無明顯相關。IL-6自然對數(LnIL-6)與SDNN呈負相關(r=-0.700,P<0.001),與RMSSD呈負相關(r=-0.457,P=0.003)。結論 UA患者HRV的降低與體內炎性標記物hs-CRP、IL-6增加相關。
목적:연구불은정심교통(UA)환자염성표지물여심솔변이성지간적관계。방법자2013년6월지2014년6월재산동중의약대학부속의원심내과주원적UA환자40례,녀성26례,남성14례,년령50~80세。장연구대상분위hs-CRP<1.0조 mg/L(n=15),hs-CRP(1.0~3.0)mg/L조(n=16), hs-CRP>3.0 mg/L조(n=9)。소유환자진행24 h동태심전도검측획취심솔변이성(HRV),계산시역지표급빈역지표。동시검측염증인자초민C반응단백(hs-CRP)화백개소-6(IL-6)함량。분석hs-CRP、IL-6적자연대수여SDNN、RMSSD적관계。결과 hs-CRP(>3 mg/L)조교hs-CRP(1~3 mg/L)조SDNN화RMSSD균강저,차이유통계학의의(P균<0.05)。각조간빈역지표비교,수hs-CRP적승고,기저빈(LF)、고빈(HF)、겁저빈(VLF)화총공솔(TP)축점강저,단각조간차이무통계학의의(P균>0.05)。단인소상관분석현시hs-CRP자연대수(Lnhs-CRP)여SDNN지간존재부상관성(r=-0.365,P=0.022),이Lnhs-CRP여RMSSD지간무명현상관。IL-6자연대수(LnIL-6)여SDNN정부상관(r=-0.700,P<0.001),여RMSSD정부상관(r=-0.457,P=0.003)。결론 UA환자HRV적강저여체내염성표기물hs-CRP、IL-6증가상관。
Objective To study the relationship between inflammatory cytokines and heart rate variability (HRV) in patients with unstable angina pectoris (UAP).Methods UAP patients (n=40, female 26, male 14 and aged from 50 to 80) were chosen from June 2013 to June 2014, and then divided into [high sensitivity C-reactive protein (hs-CRP)<1.0 mg/L group,n=15], [hs-CRP=(1.0~3.0) mg/L group,n=16], and (hs-CRP>3.0mg/L group,n=9). All patients were given 24h Holter for detecting HRV and calculating time-domain index and frequency-domain index. The levels of hs-CRP and interleukin-6 (IL-6) were detected. The relationships between the natural logarithms of hs-CRP or IL-6 and SDNN or RMSSD were analyzed.Results SDNN and RMSSD decreased inhs- CRP>3.0mg/L group compared with hs-CRP=(1.0~3.0) mg/L group (allP<0.05). The comparison in frequency-domain index showed that LF, HF, VLF and TP decreased gradually as hs-CRP increased but there was no statistical difference among all groups (allP>0.05). The single factor correlation analysis showed that the natural logarithms of hs-CRP was negatively correlated to SDNN (r=-0.365,P=0.022), while not correlated to RMSSD, and the natural logarithms of IL-6 was negatively correlated to SDNN (r=-0.700,P<0.001) and RMSSD (r=-0.457,P=0.003).Conclusion The decrease of HRV is correlated to the increases of inflammatory cytokines (hs-CRP and IL-6) in UAP patients.