CAJ | 학술논문

目的：探讨青年乳腺癌患者的临床病理特点、分子分型与预后的关系。方法选取99例青年乳腺癌患者作为研究对象；另选取同期中老年乳腺癌患者（年龄＞35岁）50例作为对照研究；回顾性分析青年乳腺癌患者的临床病理特征、分子分型及预后情况。结果3组患者肿瘤直径、临床分期、ER、HER-2、分子分型及复发转移存在统计学差异（P＜0．05）；年龄＜30岁的青年乳腺癌患者，较易出现ER和HER-2阴性、三阴性乳腺癌及复发或转移（P＜0．05）。随访生存时间8～92个月，中位生存期为51．2个月。年龄＜30岁组、年龄31～35岁组及年龄＞35岁组总生存率分别为82．5％、88．1％及98．3％，组间差异有统计学意义（P＜0．05）；3组无病生存率分别为72．3％、78．1％及88．1％，组间差异有统计学意义（P＜0．05）。肿瘤大小（＞5 cm）、复发或转移、ER阳性、乳腺根治术及分子分型是影响青年乳腺癌患者预后的主要因素（P＜0．05）；肿瘤大小（＞5 cm）、淋巴结转移及分子分型是影响青年乳腺癌患者预后的独立危险因素（P＜0．05）。结论青年乳腺癌患者的临床病理特征较为复杂，预后较差，临床应及早确诊、及早治疗，以改善患者的预后。
목적：탐토청년유선암환자적림상병리특점、분자분형여예후적관계。방법선취99례청년유선암환자작위연구대상；령선취동기중노년유선암환자（년령＞35세）50례작위대조연구；회고성분석청년유선암환자적림상병리특정、분자분형급예후정황。결과3조환자종류직경、림상분기、ER、HER-2、분자분형급복발전이존재통계학차이（P＜0．05）；년령＜30세적청년유선암환자，교역출현ER화HER-2음성、삼음성유선암급복발혹전이（P＜0．05）。수방생존시간8～92개월，중위생존기위51．2개월。년령＜30세조、년령31～35세조급년령＞35세조총생존솔분별위82．5％、88．1％급98．3％，조간차이유통계학의의（P＜0．05）；3조무병생존솔분별위72．3％、78．1％급88．1％，조간차이유통계학의의（P＜0．05）。종류대소（＞5 cm）、복발혹전이、ER양성、유선근치술급분자분형시영향청년유선암환자예후적주요인소（P＜0．05）；종류대소（＞5 cm）、림파결전이급분자분형시영향청년유선암환자예후적독립위험인소（P＜0．05）。결론청년유선암환자적림상병리특정교위복잡，예후교차，림상응급조학진、급조치료，이개선환자적예후。
Objective To investigate the relationship between clinicopathological characteristics,molecular typing and prognosis of young patients with breast cancer.Methods The clinical data of 99 cases of young patients with breast cancer were chosen as the study group,50(age>35) middle and elderly women at the same period were chosen as the control group.Clinico-pathological characteristics,molecular typy and prognosis of young patients with breast cancer were retrospectively analyzed.Re-sults Among the 3 groups,tumor diameter,clinical stage,ER,HER-2,molecular typing,recurrence and metastasis had statisti-cally significant difference(P<0.05).Patients less than 30 years old were prone to ER,HER-2 negative,triple negative breast cancer and recurrence or metastasis (P<0.05).The followe-up survival time was 8~92 months,the median survival time was 51.2 months.The overall survival rates of patients whose age <30,31~35 and >35 were 82.5%,88.1% and 98.3%( P<0.05).The disease-free survival rates of the 3 groups were 72.3%,78.1%and 88.1%(P<0.05).Tumor size (>5 cm),re-currence or metastasis,ER positive,breast radical mastectomy and molecular typing were the main factors affecting the prognosis of young patients with breast cancer (P<0.05).Tumor size (>5 cm),lymph node metastasis and molecular typing were the in-dependent prognostic factors in young patients with breast cancer (P<0.05).Conclusion The clinicopathological characteris-tics of young patients with breast cancer is complex and the prognosis is poor.Early diagnosis and treatment can improve the prog-nosis of the patients.