CAJ | 학술논문

目的：探讨奥沙利铂联合卡培他滨治疗晚期胃癌的临床疗效。方法将60例晚期胃癌患者按照住院时间先后顺序分组为对照组和观察组。对照组：采用奥沙利铂治疗，130 mg／m2，静脉滴入，1次／天。观察组：采用奥沙利铂治疗，130 mg／m2，静脉滴入，1次／天；卡培他滨2000 mg／（ m2· d）；分2次口服，第1～14天。2组患者均完成4个周期治疗，并于第4周期治疗完成时观察2组患者的临床疗效和不良反应及对细胞因子的影响及生存质量评分。结果2组患者临床疗效和不良反应比较，P＜0．05。2组患者治疗后血清IL-2和TNF-α及IFN-γ水平较治疗前均出现明显上升，但观察组升高比对照组较为显著（P＜0．05）。治疗后2组患者生存质量均明显改善，但观察组优于对照组（P＜0．05）。结论相比奥沙利铂来说，奥沙利铂联合卡培他滨治疗晚期胃癌能提高患者临床疗效，且不良反应少，同时还能有效改善患者免疫功能，提高患者抵抗力和生存质量。
목적：탐토오사리박연합잡배타빈치료만기위암적림상료효。방법장60례만기위암환자안조주원시간선후순서분조위대조조화관찰조。대조조：채용오사리박치료，130 mg／m2，정맥적입，1차／천。관찰조：채용오사리박치료，130 mg／m2，정맥적입，1차／천；잡배타빈2000 mg／（ m2· d）；분2차구복，제1～14천。2조환자균완성4개주기치료，병우제4주기치료완성시관찰2조환자적림상료효화불량반응급대세포인자적영향급생존질량평분。결과2조환자림상료효화불량반응비교，P＜0．05。2조환자치료후혈청IL-2화TNF-α급IFN-γ수평교치료전균출현명현상승，단관찰조승고비대조조교위현저（P＜0．05）。치료후2조환자생존질량균명현개선，단관찰조우우대조조（P＜0．05）。결론상비오사리박래설，오사리박연합잡배타빈치료만기위암능제고환자림상료효，차불량반응소，동시환능유효개선환자면역공능，제고환자저항력화생존질량。
Objective To investigate and analyze the clinical efficacy of oxaliplatin combined with capecitabine for ad-vanced gastric cancer.Methods 60 cases of advanced gastric cancer were grouped into the control group and the observation group in accordance with the hospitalization time.The control group received oxaliplatin,130 mg/m2,intravenous drip,once a day;the observation group received oxaliplatin,130 mg/m2 ,intravenous drip,1 times/d;capecitabine 2 000 mg/( m2 · d);twice a day orally,1~14 d.Both groups underwent 4 cycles of treatment,the clinical efficacy and adverse reactions of the 2 groups,and the effect on cell factor and the quality of life were observed after 4th cycle of treatment.Results Clinical efficacy and adverse reactions of the 2 groups were compared (P<0.05).Serum IL-2,TNF-αand IFN-γlevels of the 2 groups after treatment signifi-cantly increased,and the observation group increased more significantly than the control group(P<0.05).Quality of life of the 2 groups after treatment were significantly improved,but the observation group was superior to the control group (P<0.05).Con-clusion Compared with oxaliplatin,capecitabine combined with oxaliplatin for advanced gastric cancer can improve the clinical efficacy with less adverse reactions,and can effectively improve the immune function,resistance and quality of life of patients.