浙江医学教育
浙江醫學教育
절강의학교육
Zhejiang Medical Education
2015年
2期
61-63
,共3页
妊娠期肝内胆汁淤积症%游离脂肪酸%总胆汁酸%甘胆酸
妊娠期肝內膽汁淤積癥%遊離脂肪痠%總膽汁痠%甘膽痠
임신기간내담즙어적증%유리지방산%총담즙산%감담산
intrahepatic cholestasis disease during pregnancy%free fatty acids .total bile acid%gansucholic acid
目的:探讨孕妇妊娠晚期血清游离脂肪酸(FFA ),总胆汁酸(TBA ),甘胆酸(GC )检测在诊断妊娠期胆汁淤积症(ICP )中的意义。方法:分别用酶法、酶循环法和化学发光法测定TCP组(121例)和正常孕妇组(125例)的FFA、TBA、GC ,比较2组间的差异,并用ROC曲线分析FFA、TBA、GC在ICP诊断中的意义。结果:ICP组FFA、TBA、GC水平均明显高于正常孕妇组( P<0.05);ROC曲线下面积,FFA (0.9991)>GC (0.9449)>TBA (0.8832);正确诊断指数, FFA (0.9917)>GC (0.9008)>TBA (0.7366)。结论:FFA可作为ICP早期诊断的重要指标,FFA和GC联合检测有一定的临床意义。
目的:探討孕婦妊娠晚期血清遊離脂肪痠(FFA ),總膽汁痠(TBA ),甘膽痠(GC )檢測在診斷妊娠期膽汁淤積癥(ICP )中的意義。方法:分彆用酶法、酶循環法和化學髮光法測定TCP組(121例)和正常孕婦組(125例)的FFA、TBA、GC ,比較2組間的差異,併用ROC麯線分析FFA、TBA、GC在ICP診斷中的意義。結果:ICP組FFA、TBA、GC水平均明顯高于正常孕婦組( P<0.05);ROC麯線下麵積,FFA (0.9991)>GC (0.9449)>TBA (0.8832);正確診斷指數, FFA (0.9917)>GC (0.9008)>TBA (0.7366)。結論:FFA可作為ICP早期診斷的重要指標,FFA和GC聯閤檢測有一定的臨床意義。
목적:탐토잉부임신만기혈청유리지방산(FFA ),총담즙산(TBA ),감담산(GC )검측재진단임신기담즙어적증(ICP )중적의의。방법:분별용매법、매순배법화화학발광법측정TCP조(121례)화정상잉부조(125례)적FFA、TBA、GC ,비교2조간적차이,병용ROC곡선분석FFA、TBA、GC재ICP진단중적의의。결과:ICP조FFA、TBA、GC수평균명현고우정상잉부조( P<0.05);ROC곡선하면적,FFA (0.9991)>GC (0.9449)>TBA (0.8832);정학진단지수, FFA (0.9917)>GC (0.9008)>TBA (0.7366)。결론:FFA가작위ICP조기진단적중요지표,FFA화GC연합검측유일정적림상의의。
Objective] To investigate the significance of serum free fatty acid (FFA) and total bile acid (associates) ,gansu-cholic acid (GC) measurement in pregnant women with late pregnancy for diagnosis of cholestasis syndrome during pregnancy (ICP) .[Method] Enzymatic ,enzyme recycling method and chemical luminescence method were carried out to determine above indexes in TCP group (121 cases ) and normal pregnant women (125 cases ) .We compared the differences between two groups using ROC curve analysis .[Result] FFA and CG levels of ICP group were significantly higher than that of normal preg-nant women ( p<0 .05 ) .The area under the ROC curve:FFA (0 .9991 ) > GC (0 .9449 ) > TBA (0 .8832 ) .Correct diag-nosis index:FFA (0 .9917) > GC (0 .9008) > associates (0 .7366) .[Conclusion] FFA can be used as an important index in early diagnosis of ICP .FFA and GC joint detection has a certain clinical significance .