CAJ | 학술논문

目的：探讨血清白介素-15（ interleukin-15，IL-15）水平与膝骨关节炎患者影像学改变程度的相关性。方法选择102名膝骨关节炎（ osteoarthritis，OA）患者为OA组，54名健康体检者作为对照组。采用酶联免疫吸附法测定血清IL-15水平；采用Kellgren-Lawrence（ KL）标准评价膝骨关节炎患者影像学改变的程度。结果 OA组KL2级、KL3级、KL4级患者的血清IL-15水平较对照组显著升高（均P＜0．05）。 OA组患者血清IL-15水平与KL分级呈显著正相关（r＝0．433，P＜0．01）。结论膝骨关节炎患者血清IL-15水平与影像学改变程度呈显著正相关。
목적：탐토혈청백개소-15（ interleukin-15，IL-15）수평여슬골관절염환자영상학개변정도적상관성。방법선택102명슬골관절염（ osteoarthritis，OA）환자위OA조，54명건강체검자작위대조조。채용매련면역흡부법측정혈청IL-15수평；채용Kellgren-Lawrence（ KL）표준평개슬골관절염환자영상학개변적정도。결과 OA조KL2급、KL3급、KL4급환자적혈청IL-15수평교대조조현저승고（균P＜0．05）。 OA조환자혈청IL-15수평여KL분급정현저정상관（r＝0．433，P＜0．01）。결론슬골관절염환자혈청IL-15수평여영상학개변정도정현저정상관。
Objective To understand any possible correlation of serum interleukin-15 (interleukin-15,IL-15) level to knee osteoarthritis ( OA) patients.Method 102 OA patients were chosen to be the experimental group and 54 healthy were chosen to be the control group. Serum IL-15 levels were determined by enzyme-linked immunosorbent assay. The radiographic disease severity of OA was assessed by Kellgren-Lawrence ( KL) grading system.The data obtained were then subjected to statistical analysis.Findings The serum IL-15 levels of the KL2 level, KL3 level, and KL4 level patients in the experimental group were significantly higher than those of the control group (P<0.05).The levels of serum IL-15 were found to be positively correlated with KL grading scores in the experimental group (r=0.433, P<0.01).Conclusion Serum IL-15 levels were associated with radiographic disease severity of OA patients.These results demonstrated that IL-15 might serve as a potential indicator of the severity and progression of knee OA.