实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2015年
4期
556-558,562
,共4页
淋巴结转移度%大肠癌%远处转移%5年生存率
淋巴結轉移度%大腸癌%遠處轉移%5年生存率
림파결전이도%대장암%원처전이%5년생존솔
Lymph node ratio%Colorectal cancer%Distant metastasis%5-year survival
目的:探讨淋巴结转移度对Ⅲ期大肠癌患者手术后发生远处转移的影响情况。方法选取153例Ⅲ期大肠癌患者,采用回顾性调查的方法,分析淋巴结转移度对患者术后转移情况及5年生存率的影响。结果淋巴结转移度≤0.02的Ⅲ期大肠癌患者术后发生远处转移的占34.29%,远低于淋巴结转移度>0.02患者的85.42%,差异具有统计学意义,P<0.05。肿瘤分化情况和淋巴结转移度是患者手术后发生远处转移的危险因素,P<0.05;淋巴结转移度较高的患者术后发生远处转移比例较高,术后生存时间及5年生存率均较低,差异具有统计学意义,P<0.05。结论淋巴结转移度越高,Ⅲ期大肠癌患者手术后发生远处转移的可能性越大,术后生存时间越短。检测淋巴结转移度可以很好地预测大肠癌患者预后情况,值得临床推广。
目的:探討淋巴結轉移度對Ⅲ期大腸癌患者手術後髮生遠處轉移的影響情況。方法選取153例Ⅲ期大腸癌患者,採用迴顧性調查的方法,分析淋巴結轉移度對患者術後轉移情況及5年生存率的影響。結果淋巴結轉移度≤0.02的Ⅲ期大腸癌患者術後髮生遠處轉移的佔34.29%,遠低于淋巴結轉移度>0.02患者的85.42%,差異具有統計學意義,P<0.05。腫瘤分化情況和淋巴結轉移度是患者手術後髮生遠處轉移的危險因素,P<0.05;淋巴結轉移度較高的患者術後髮生遠處轉移比例較高,術後生存時間及5年生存率均較低,差異具有統計學意義,P<0.05。結論淋巴結轉移度越高,Ⅲ期大腸癌患者手術後髮生遠處轉移的可能性越大,術後生存時間越短。檢測淋巴結轉移度可以很好地預測大腸癌患者預後情況,值得臨床推廣。
목적:탐토림파결전이도대Ⅲ기대장암환자수술후발생원처전이적영향정황。방법선취153례Ⅲ기대장암환자,채용회고성조사적방법,분석림파결전이도대환자술후전이정황급5년생존솔적영향。결과림파결전이도≤0.02적Ⅲ기대장암환자술후발생원처전이적점34.29%,원저우림파결전이도>0.02환자적85.42%,차이구유통계학의의,P<0.05。종류분화정황화림파결전이도시환자수술후발생원처전이적위험인소,P<0.05;림파결전이도교고적환자술후발생원처전이비례교고,술후생존시간급5년생존솔균교저,차이구유통계학의의,P<0.05。결론림파결전이도월고,Ⅲ기대장암환자수술후발생원처전이적가능성월대,술후생존시간월단。검측림파결전이도가이흔호지예측대장암환자예후정황,치득림상추엄。
Objective 153 cases of stage Ⅲ colorectal cancer patients were retrospectively analyzed.Effect of lymph node ratio on distant metastasis and 5-year survival rate were analyzed.Methods Steroid saponins of the flowers of Cestrum Noc-turnum,Linn(SSFCN) were separated and identified their structures by solvent.The K562 cells were cultured in vitro and the cell growth inhibition was measured by MTT assay after treatment with SSFCN,The effect of SSFCN on apoptotic induction in K562 cells was determined using the DNA ladder agarose gel electrophoresis.Alteration of cell cycle and apoptosis rate was defected by flow cytometry.The expression of AKt,and phosphorylated AKt(p-AKt) was detected by Western blot.Results Lymph node me-tastasis rate of stageⅢcolorectal cancer patients with lymph node ratio≤0.02 was 34.29%,which was lower than patients with lymph node ratio >0.02(85.42%),the difference was statistically significant,P<0.05.Tumor differentiation and lymph node metastasis rate were risk factors for distant metastasis after surgery,P<0.05;Patients with higher degree of lymph node metastasis had higher proportion of distant metastasis,and lower survival time,and 5-year survival rate,the difference was statistically signifi-cant,P<0.05.Conclusion The higher the degree of lymph node metastasis,the greater the possibility of distant lymph node metastasis in stageⅢcolorectal cancer patients after surgery,and the shorter the survival time.Detection of lymph node metastasis rate can be a good predictor of the prognosis of patients with colorectal cancer,it is worthy of promotion.