中国医疗器械信息
中國醫療器械信息
중국의료기계신식
CHINA MEDICAL DEVICES INFORMATION
2015年
4期
50-53
,共4页
刘珍珍%杨丽萍%陈能%王文荣
劉珍珍%楊麗萍%陳能%王文榮
류진진%양려평%진능%왕문영
三氯生%超分子水凝胶%缓释%抗菌
三氯生%超分子水凝膠%緩釋%抗菌
삼록생%초분자수응효%완석%항균
Triclosan%supramolecular hydrogel%controled release%antibacterial
目的：本论文制备了一种可负载、缓释疏水的三氯生且可长时间保持其生物活性的水凝胶材料。方法：利用两亲性Pluronic F-88的疏水作用负载三氯生，再利用α-环糊精与F-88的相互作用形成水凝胶。表征水凝胶的物理性质，并考察三氯生的体外释放行为和生物活性。结果：该水凝胶对三氯生有良好的负载和缓释效果，且可长时间保持三氯生的生物活性。结论：该凝胶材料有良好的剪切变稀的性质和触变性能，可作为可注射药物载体和凝胶敷料进行应用。
目的：本論文製備瞭一種可負載、緩釋疏水的三氯生且可長時間保持其生物活性的水凝膠材料。方法：利用兩親性Pluronic F-88的疏水作用負載三氯生，再利用α-環糊精與F-88的相互作用形成水凝膠。錶徵水凝膠的物理性質，併攷察三氯生的體外釋放行為和生物活性。結果：該水凝膠對三氯生有良好的負載和緩釋效果，且可長時間保持三氯生的生物活性。結論：該凝膠材料有良好的剪切變稀的性質和觸變性能，可作為可註射藥物載體和凝膠敷料進行應用。
목적：본논문제비료일충가부재、완석소수적삼록생차가장시간보지기생물활성적수응효재료。방법：이용량친성Pluronic F-88적소수작용부재삼록생，재이용α-배호정여F-88적상호작용형성수응효。표정수응효적물이성질，병고찰삼록생적체외석방행위화생물활성。결과：해수응효대삼록생유량호적부재화완석효과，차가장시간보지삼록생적생물활성。결론：해응효재료유량호적전절변희적성질화촉변성능，가작위가주사약물재체화응효부료진행응용。
Objective: A hydrogel which could load and sustainedly release hydrophobic triclosan has been prepared.Methods: Amphiphilic Pluronic F-88 is used to load triclosan due to their hydrophobic interactions. Then, the triclosan-loaded F-88 miceles interact withα-cyclodextrin to form the hydrogel. The physical properties of the obtained hydrogel are characterized, and the in vitro release and bioactivity of triclosan are also studied.Results: The obtained hydrogel could load and controled release triclosan, also contained the bioactivity of triclosan for a long time.Conclusion: The hydrogel shows the shear-thinning and thixotropic propertoes, which could be used as injectable drug carrier of gel dressing.
