CAJ | 학술논문

目的：研究肺靶向姜黄素明胶微球在大鼠体内的器官靶向性。方法分别尾静脉给予大鼠姜黄素明胶微球和姜黄素注射液,高效液相色谱法测定各器官姜黄素含量,采用DAS2.0版软件计算药动学参数,用靶向效率来评价其在大鼠体内的组织分布及靶向性。结果姜黄素明胶微球在心、肝、脾、肺、肾的靶向效率分别为0.875,0.121,1.182,5.834,0.896。结论姜黄素明胶微球具有很好的肺靶向作用,有利于药物的肺靶向治疗研究。
목적：연구폐파향강황소명효미구재대서체내적기관파향성。방법분별미정맥급여대서강황소명효미구화강황소주사액,고효액상색보법측정각기관강황소함량,채용DAS2.0판연건계산약동학삼수,용파향효솔래평개기재대서체내적조직분포급파향성。결과강황소명효미구재심、간、비、폐、신적파향효솔분별위0.875,0.121,1.182,5.834,0.896。결론강황소명효미구구유흔호적폐파향작용,유리우약물적폐파향치료연구。
Objective To observe the targeting effect of curcumin gelatin microsphere in rats in vivo. Methods Injections of curcumin gelatin microsphere and curcumin were injected via tail vein, respectively. HPLC was used to determine the content of curcumin in different organs. The pharmacokinetic parameters were calculated on the basis of compartment models by using DAS 2. 0 program. Targeting efficiency was used to evaluate tissue distribution of curcumin. Results Targeting efficiency of curcumin gelatin microsphere in heart, liver, spleen, lung and kidney was 0. 875, 0. 121, 1. 182, 5. 834 and 0. 896, respectively. Conclusion Curcumine gelatin microspheres can improve lung-targeting efficiency, and benefit for study on lung targeting therapeutic effect.