实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2015年
4期
597-599,602
,共4页
包德强%吴畅%李泳彗%朱佑强
包德彊%吳暢%李泳彗%硃祐彊
포덕강%오창%리영혜%주우강
鼻咽癌%单纯常规外照射放疗%临床效果%影响因素
鼻嚥癌%單純常規外照射放療%臨床效果%影響因素
비인암%단순상규외조사방료%림상효과%영향인소
Nasopharyngeal carcinoma%Conventional external beam radiotherapy alone%Clinical efficacy%Influencing factors
目的：探讨单纯常规外照射放疗对初治鼻咽癌的临床效果及其影响因素分析。方法对110例行常规放疗的原发鼻咽癌患者进行单纯常规外照射放疗，评价临床效果，并随访病例。运用Cox回归模型分析5年存活率的相关影响因素。结果110例鼻咽癌患者经照射放疗后，显效75例，有效27例，无效8例，治疗有效率为92．7％。5年内死亡47例，存活63例，5年总生存率为57．3％。对疗效影响因素进行单因素分析，结果显示患者年龄、临床分期、T分期、N分期、颅神经受侵、颅底受侵、放疗剂量及PS评分与鼻咽癌的放疗预后呈显著相关（P＜0．05）；Cox回归分析结果显示，患者年龄、T分期、N分期与是否出现颅底受侵可作为鼻咽癌放疗的独立预后因素（P＜0．05）。结论采用单纯常规外照射放疗治疗鼻咽癌效果显著，安全性高；年龄、T、N分期以及是否出现颅底受侵为鼻咽癌放射治疗的独立预后因素。
目的：探討單純常規外照射放療對初治鼻嚥癌的臨床效果及其影響因素分析。方法對110例行常規放療的原髮鼻嚥癌患者進行單純常規外照射放療，評價臨床效果，併隨訪病例。運用Cox迴歸模型分析5年存活率的相關影響因素。結果110例鼻嚥癌患者經照射放療後，顯效75例，有效27例，無效8例，治療有效率為92．7％。5年內死亡47例，存活63例，5年總生存率為57．3％。對療效影響因素進行單因素分析，結果顯示患者年齡、臨床分期、T分期、N分期、顱神經受侵、顱底受侵、放療劑量及PS評分與鼻嚥癌的放療預後呈顯著相關（P＜0．05）；Cox迴歸分析結果顯示，患者年齡、T分期、N分期與是否齣現顱底受侵可作為鼻嚥癌放療的獨立預後因素（P＜0．05）。結論採用單純常規外照射放療治療鼻嚥癌效果顯著，安全性高；年齡、T、N分期以及是否齣現顱底受侵為鼻嚥癌放射治療的獨立預後因素。
목적：탐토단순상규외조사방료대초치비인암적림상효과급기영향인소분석。방법대110례행상규방료적원발비인암환자진행단순상규외조사방료，평개림상효과，병수방병례。운용Cox회귀모형분석5년존활솔적상관영향인소。결과110례비인암환자경조사방료후，현효75례，유효27례，무효8례，치료유효솔위92．7％。5년내사망47례，존활63례，5년총생존솔위57．3％。대료효영향인소진행단인소분석，결과현시환자년령、림상분기、T분기、N분기、로신경수침、로저수침、방료제량급PS평분여비인암적방료예후정현저상관（P＜0．05）；Cox회귀분석결과현시，환자년령、T분기、N분기여시부출현로저수침가작위비인암방료적독립예후인소（P＜0．05）。결론채용단순상규외조사방료치료비인암효과현저，안전성고；년령、T、N분기이급시부출현로저수침위비인암방사치료적독립예후인소。
Objective To discuss the clinical effects and influencing factors of conventional external beam radiotherapy alone for primary nasopharyngeal carcinoma ( PNC) .Methods 110 cases of PNC received conventional radiotherapy were cho-sen as research objects,and were given conventional external beam radiotherapy alone.Clinical effect was evaluated and patients were given follow-up visits.Relevant influencing factors of 5-year survival rate were analyzed by Cox regression model.Results After radiotherapy,among 110 patients,there were 75 cases with excellent clinical effects,27 with good clinical effects and 8 with no clinical effects,and total effective rate was 92.7%;within 5 years,47 patients died and 63 survived,and 5-year survival rate was 57.3%;single factor analysis showed that,age,clinical stage,T stage,N stage,cranial nerve erosion,skull base erosion,radio-therapy dose and PS score were closely related to prognosis of PNC after radiotherapy (P<0.05).Cox regression analysis showed that age,T stage,N stage,whether there was skull base erosion,were independent prognosis factors of PNC after radiotherapy ( P<0.05).Conclusion Conventional external beam radiotherapy alone for PNC has obvious clinical effects and high safety;age, T stage,N stage,whether there is skull base erosion,are independent prognosis factors of PNC after radiotherapy.
