CAJ | 학술논문

目的：探讨不同的放化疗方法治疗Ⅲ期食管癌患者的临床效果。方法将Ⅲ期食管癌患者随机分为组1和组2。组1采用同步放化疗，组2采用序贯放化疗，比较2组患者的疗效和不良反应。结果组1中32例患者，CR 6例，PR 17例，SD 4例，PD 5例，RR 71．9％；组2中32例患者，CR 4例，PR 16例，SD 6例，PD 6例，RR 62．5％。经统计分析，2组患者临床疗效的差异不具有统计学意义，P＞0．05。组1中，4例患者血小板轻度下降，5例恶心呕吐，7例白细胞下降；组2中，8例患者血小板轻度下降，19例恶心呕吐，21例白细胞下降。经统计分析，2组患者的恶心呕吐和白细胞轻度下降的差异具有统计学差异，P＜0．05。结论同步放化疗治疗Ⅲ期食管癌患者效果显著，值得进一步的推广和应用。
목적：탐토불동적방화료방법치료Ⅲ기식관암환자적림상효과。방법장Ⅲ기식관암환자수궤분위조1화조2。조1채용동보방화료，조2채용서관방화료，비교2조환자적료효화불량반응。결과조1중32례환자，CR 6례，PR 17례，SD 4례，PD 5례，RR 71．9％；조2중32례환자，CR 4례，PR 16례，SD 6례，PD 6례，RR 62．5％。경통계분석，2조환자림상료효적차이불구유통계학의의，P＞0．05。조1중，4례환자혈소판경도하강，5례악심구토，7례백세포하강；조2중，8례환자혈소판경도하강，19례악심구토，21례백세포하강。경통계분석，2조환자적악심구토화백세포경도하강적차이구유통계학차이，P＜0．05。결론동보방화료치료Ⅲ기식관암환자효과현저，치득진일보적추엄화응용。
Objective To investigate the clinical efficacy of different chemoradiotherapy for stageⅢesophageal carcino-ma.Methods Patients with stageⅢ esophageal carcinoma were randomly divided into group 1 and group 2.Group 1 received concurrent chemoradiotherapy,group 2 was treated with sequential chemoradiotherapy,the efficacy and adverse reactions of the 2 groups were compared.Results There were 32 cases in group 1,including CR 6 cases,PR 17 cases,SD 4 cases,PD 5 cases,RR was 71.9%;there were 32 cases in group 2,including CR 4 cases,PR 16 cases,SD 6 cases,PD 6 cases,RR was 62.5%.After statistical analysis,there had no statistical significant differences in clinical efficacy between the 2 groups,P>0.05.In group 1,4 cases had mild thrombocytopenia,5 cases had nausea and vomiting,7 cases had leukopenia;in group 2,8 case shad mild thrombo-cytopenia,19 cases had nausea and vomiting,21 cases had leukopenia.After statistical analysis,there had statistical significant differences in nausea and vomiting and leukopenia between the 2 groups,P<0.05.Conclusion Concurrent chemoradiotherapy for stageⅢesophageal cancer is effective,and it is worthy of further promotion and application.