实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2015年
4期
575-576,579
,共3页
高危型HPV%TCT%漏诊%LEEP%宫颈上皮内瘤变( CIN)
高危型HPV%TCT%漏診%LEEP%宮頸上皮內瘤變( CIN)
고위형HPV%TCT%루진%LEEP%궁경상피내류변( CIN)
High-risk HPV%Thinprep cytologic test ( TCT )%Misdiagnosis%LEEP%Cervical intraepithelial neoplasia ( CIN)
目的：探讨高危型HPV与TCT联合筛查时CIN病变漏诊情况。方法收集高危型HPV阳性、TCT阴性并有宫颈活检或LEEP刀手术切除标本433例，并与同期高危型HPV及TCT均阴性并有宫颈LEEP刀手术切除标本618例比较，分析各自CIN病例数。结果 HPV（＋）组确诊有CIN Ⅰ6例，CIN Ⅱ3例，CIN Ⅲ2例，检出率2．54％；HPV （－）组有CINⅠ1例，CINⅡ1例，检出率0．32％；两者比较，差异有统计学意义（P＜0．005）。同时，HPV（＋）组高级别CIN检出率较高，两者比较，差异有统计学意义（P＜0．05）。说明虽然TCT为阴性，但HPV（＋）组CIN检出率明显高于HPV（－）组，HPV（＋）组CIN漏诊率及高级别CIN漏诊率均较高。结论对HPV（＋）和TCT（－）病例，应积极采取措施，避免漏诊病例发展为严重病变。
目的：探討高危型HPV與TCT聯閤篩查時CIN病變漏診情況。方法收集高危型HPV暘性、TCT陰性併有宮頸活檢或LEEP刀手術切除標本433例，併與同期高危型HPV及TCT均陰性併有宮頸LEEP刀手術切除標本618例比較，分析各自CIN病例數。結果 HPV（＋）組確診有CIN Ⅰ6例，CIN Ⅱ3例，CIN Ⅲ2例，檢齣率2．54％；HPV （－）組有CINⅠ1例，CINⅡ1例，檢齣率0．32％；兩者比較，差異有統計學意義（P＜0．005）。同時，HPV（＋）組高級彆CIN檢齣率較高，兩者比較，差異有統計學意義（P＜0．05）。說明雖然TCT為陰性，但HPV（＋）組CIN檢齣率明顯高于HPV（－）組，HPV（＋）組CIN漏診率及高級彆CIN漏診率均較高。結論對HPV（＋）和TCT（－）病例，應積極採取措施，避免漏診病例髮展為嚴重病變。
목적：탐토고위형HPV여TCT연합사사시CIN병변루진정황。방법수집고위형HPV양성、TCT음성병유궁경활검혹LEEP도수술절제표본433례，병여동기고위형HPV급TCT균음성병유궁경LEEP도수술절제표본618례비교，분석각자CIN병례수。결과 HPV（＋）조학진유CIN Ⅰ6례，CIN Ⅱ3례，CIN Ⅲ2례，검출솔2．54％；HPV （－）조유CINⅠ1례，CINⅡ1례，검출솔0．32％；량자비교，차이유통계학의의（P＜0．005）。동시，HPV（＋）조고급별CIN검출솔교고，량자비교，차이유통계학의의（P＜0．05）。설명수연TCT위음성，단HPV（＋）조CIN검출솔명현고우HPV（－）조，HPV（＋）조CIN루진솔급고급별CIN루진솔균교고。결론대HPV（＋）화TCT（－）병례，응적겁채취조시，피면루진병례발전위엄중병변。
Objective To study the misdiagnosis of high-risk HPV combined with thinprep cytologic test ( TCT ) in screening cervical intraepithelial neoplasia ( CIN) .Methods 433 cases of high-disk HPV-positive,TCT-negative and cervical bi-opsy or LEEP operation,and 618 cases of high-risk HPV-negative,TCT-negative and cervical biopsy or LEEP operation were com-pared,their respective CIN cases were analyzed.Results In the HPV-positive group,6 cases were confirmed to be CINⅠ,3 ca-ses were confirmed to be CINⅡ,2 cases were confirmed to be CINⅢ,the total detection rate was 2.54%.In the HPV-negative group,1 case were CINⅠ,1 case were CINⅡ,the detection rate was 0.32%.There was statistically significant difference be-tween the 2 groups ( P<0.005) .Meanwhile,the detection rate of high grade CIN in HPV-positive group was higher than that of HPV-negative group,there was statistically significant difference between the 2 groups (P<0.05).Although TCT was negative, the detection rate in HPV-positive group was higher than that of HPV-negative group,misdiagnosis rates of CIN and high grade CIN were higher.Conclusion To the high-risk HPV-negative and TCT-negative cases,positive measures should be taken to a-void misdiagnosis cases developing into severe lesions.
