CAJ | 학술논문

目的：优化魔芋胶-丹皮酚骨架片的处方。方法采用正交实验设计,以体外累积释放度为指标,考察魔芋胶( KGM)的黏度、KGM和乳糖的用量3个影响因素,筛选对KGM-丹皮酚骨架片的最佳处方。结果最佳处方为KGM的黏度为20000 mPa·s,KGM 30%,乳糖20%,体外释放度实验表明其体外释药符合Higuchi方程。结论 KGM-丹皮酚骨架片处方合理,具有良好的体外缓释效果。
목적：우화마우효-단피분골가편적처방。방법채용정교실험설계,이체외루적석방도위지표,고찰마우효( KGM)적점도、KGM화유당적용량3개영향인소,사선대KGM-단피분골가편적최가처방。결과최가처방위KGM적점도위20000 mPa·s,KGM 30%,유당20%,체외석방도실험표명기체외석약부합Higuchi방정。결론 KGM-단피분골가편처방합리,구유량호적체외완석효과。
Objective To optimize the formula of konjac glucomannan-paeonol matrix tablets. Methods The formula of paeonol matrix tablets was optimized by the orthogonal design with the accumulative release rate in vitro as index, with the viscosity of konjac glucomannan ( KGM) , the amount of KGM and lactose as influence factors. Results The optimized formula was as follows:the viscosity of konjac glucomannan was 20 000 mPa·s, KGM 30%, lactose 20% and the release in vitro fit into the Higuchi equation. Conclusion The formula of the paeonol matrix tablets is reasonable and the tablets have well release effect in vitro.