CAJ | 학술논문

目的：观察康艾注射液治疗肝癌的疗效，探讨其对肝癌患者补体系统和纤维化状态的影响。方法将130例选择肝动脉化疗栓塞术（ TACE术）的原发性肝癌患者随机分为2组，对照组和观察组各65例。对照组采用对症治疗和支持治疗，观察组则在此基础上加用康艾注射液。比较2组间疗效差异；治疗前后血清补体C3、C4、CH50水平和红细胞CD55、CD59表达差异，血清肝纤维化指标HA、LN、PC-Ⅲ、Ⅳ-C水平差异。结果2组患者间症状缓解等级和近期疗效等级比较均有统计学差异（P＜0．05）。治疗后1、2 W，观察组血清C3、C4、CH50水平显著高于对照组（P＜0．05）；观察组血清HA、LN、PC-Ⅲ、Ⅳ-C水平显著低于对照组（P＜0．05）。结论肝癌TACE术联合康艾注射液治疗，能增加血清补体水平，下调肝纤维化因子，有效改善肝癌患者的肝功能并提高化疗的疗效。
목적：관찰강애주사액치료간암적료효，탐토기대간암환자보체계통화섬유화상태적영향。방법장130례선택간동맥화료전새술（ TACE술）적원발성간암환자수궤분위2조，대조조화관찰조각65례。대조조채용대증치료화지지치료，관찰조칙재차기출상가용강애주사액。비교2조간료효차이；치료전후혈청보체C3、C4、CH50수평화홍세포CD55、CD59표체차이，혈청간섬유화지표HA、LN、PC-Ⅲ、Ⅳ-C수평차이。결과2조환자간증상완해등급화근기료효등급비교균유통계학차이（P＜0．05）。치료후1、2 W，관찰조혈청C3、C4、CH50수평현저고우대조조（P＜0．05）；관찰조혈청HA、LN、PC-Ⅲ、Ⅳ-C수평현저저우대조조（P＜0．05）。결론간암TACE술연합강애주사액치료，능증가혈청보체수평，하조간섬유화인자，유효개선간암환자적간공능병제고화료적료효。
Objective To observeation the efficacy of Kang’ ai injection and its influence on the complement system and fibrosis state of patients with hepatic carcinoma.Methods 130 case of patients with primary hepatic carcinoma who selected treated with hepatic artery chemoembolization( TACE) were randomly divided into 2 groups,each with 65 cases.control group and observation group,each group had 65 cases, patients in The control observation group were tookreceived symptomatic treatment and supportive care,and patients in the observation control group were treated by combined withreceived Kang’ ai injection on the basis of the control group.Then the eEfficacy,serum levels of complement C3,C4,CH50 and erythrocyte CD55,CD59 expression, and serum levels of liver fibrosis HA,LN,PC-Ⅲ,Ⅳ-C of twothe 2 groups were compared.Results There was significant differ-ence ofin symptoms grade rating and short-term efficacy between the 2 groups (P<0.05),the observation group was better than the control group.After 1,1~2 weeks ofafter treatment,the serum levels of C3,C4,CH50 in theof observation group were all sig-nificantly higher than that of the control group (P<0.05),while the serum levels of liver fibrosis HA,LN,PC-Ⅲ,Ⅳ-C were sig-nificantly lower than that of the control group,(P<0.05)all P<0.05.Conclusion TACE combined with Kang’ai injection can effectively improve the serum levels of complement,reduce liver fibrosis factor for of hepatic carcinoma patients undergoing TA-CE,and improve liver function and chemotherapy efficacy,kangai injection has a positive role in the treatment of liver cancer.