延边医学
延邊醫學
연변의학
YAN BIAN YI XUE
2015年
13期
208-209
,共2页
B7-H3%神经胶质瘤%免疫逃逸
B7-H3%神經膠質瘤%免疫逃逸
B7-H3%신경효질류%면역도일
B7- H3%glioma%immunological escaping
目的：：通过对不同级别的神经胶质瘤（glioma）组织中共刺激分子B7- H3的检测，进一步探讨B7- H3在神经胶质瘤免疫逃逸过程中的作用机制，为神经胶质瘤临床免疫治疗提供理论基础和实验依据。方法：采用免疫组化法，检测58例神经胶质瘤患者瘤组织和9例正常脑组织中B7- H3的表达，并分析B7- H3的表达与神经胶质瘤生物学行为及愈后之间的关系。结果：58例不同级别的胶质瘤组织均表达B7- H3，9例正常脑组织中发现很少有B7- H3的表达，低级别（1～2级）及高级别（3～4级）胶质瘤组与正常脑组织组之间B7- H3的表达分别有差异性（P<0.05）,低级别（1～2级）胶质瘤组与高级别（3～4级）胶质瘤组之间有明显差异性（P<0.05），B7- H3的表达与患者的年龄、性别无关，与病理级别及愈后有关，生存期超过2年的神经胶质瘤患者B7- H3阳性表达率显著高于生存期短于2年的胶质瘤患者( P﹤0.01)。结论：B7- H3的表达与神经胶质瘤具有相关性，随神经胶质瘤病理级别的增高而降低，在神经胶质瘤的免疫逃逸过程中有重要作用，可以作为反映神经胶质瘤生物学行为和患者预后的一个新的指标；并为神经胶质瘤免疫逃逸机制的进一步研究提供了线索，为临床制定合理的治疗方案、预后判断及疗效评定提供客观参考依据。
目的：：通過對不同級彆的神經膠質瘤（glioma）組織中共刺激分子B7- H3的檢測，進一步探討B7- H3在神經膠質瘤免疫逃逸過程中的作用機製，為神經膠質瘤臨床免疫治療提供理論基礎和實驗依據。方法：採用免疫組化法，檢測58例神經膠質瘤患者瘤組織和9例正常腦組織中B7- H3的錶達，併分析B7- H3的錶達與神經膠質瘤生物學行為及愈後之間的關繫。結果：58例不同級彆的膠質瘤組織均錶達B7- H3，9例正常腦組織中髮現很少有B7- H3的錶達，低級彆（1～2級）及高級彆（3～4級）膠質瘤組與正常腦組織組之間B7- H3的錶達分彆有差異性（P<0.05）,低級彆（1～2級）膠質瘤組與高級彆（3～4級）膠質瘤組之間有明顯差異性（P<0.05），B7- H3的錶達與患者的年齡、性彆無關，與病理級彆及愈後有關，生存期超過2年的神經膠質瘤患者B7- H3暘性錶達率顯著高于生存期短于2年的膠質瘤患者( P﹤0.01)。結論：B7- H3的錶達與神經膠質瘤具有相關性，隨神經膠質瘤病理級彆的增高而降低，在神經膠質瘤的免疫逃逸過程中有重要作用，可以作為反映神經膠質瘤生物學行為和患者預後的一箇新的指標；併為神經膠質瘤免疫逃逸機製的進一步研究提供瞭線索，為臨床製定閤理的治療方案、預後判斷及療效評定提供客觀參攷依據。
목적：：통과대불동급별적신경효질류（glioma）조직중공자격분자B7- H3적검측，진일보탐토B7- H3재신경효질류면역도일과정중적작용궤제，위신경효질류림상면역치료제공이론기출화실험의거。방법：채용면역조화법，검측58례신경효질류환자류조직화9례정상뇌조직중B7- H3적표체，병분석B7- H3적표체여신경효질류생물학행위급유후지간적관계。결과：58례불동급별적효질류조직균표체B7- H3，9례정상뇌조직중발현흔소유B7- H3적표체，저급별（1～2급）급고급별（3～4급）효질류조여정상뇌조직조지간B7- H3적표체분별유차이성（P<0.05）,저급별（1～2급）효질류조여고급별（3～4급）효질류조지간유명현차이성（P<0.05），B7- H3적표체여환자적년령、성별무관，여병리급별급유후유관，생존기초과2년적신경효질류환자B7- H3양성표체솔현저고우생존기단우2년적효질류환자( P﹤0.01)。결론：B7- H3적표체여신경효질류구유상관성，수신경효질류병리급별적증고이강저，재신경효질류적면역도일과정중유중요작용，가이작위반영신경효질류생물학행위화환자예후적일개신적지표；병위신경효질류면역도일궤제적진일보연구제공료선색，위림상제정합리적치료방안、예후판단급료효평정제공객관삼고의거。
Objective: Through exploring the expressions of costimulatory molecules B7- H3 with gliomas, To investigate the relationship between B7- H3 and the immunological escaping mechanism of gliomas,and offer theoretical and experimental evidence for studying gliomas.Methods: The protein expression of B7- H3 was examined by immunohistochemical method in 58 gliomas and 9 normal brains. The relationship between the expression levels of B7- H3 and the glioma biological behaviors was analyzed . Results:Expression of B7- H3 were found in 58 gliomas, very little in 9 normal brains. The ex-pression level of B7- H3 reduced obviously accompany with the incrasing of the grade of gliomas (P<0.05). Each group was significantly different(P<0.05). B7- H3 expression was not related to age and sex, There was a close correlation between B7- H3 expression and several factors, such as histologic types and prognosis (P<0.05) .The positive rate of B7- H3 expression in patients more than two years survival were significantly higher than that in patients less than two years survival (P<0.05). Conclusions:There was a close correlation between B7- H3 and glioma ,the expression of B7- H3 reduced with the increase of grades of glioma, Detection of B7- H3 expression in gliomas wil be beneficial to the judgment the biological behaviors and prognosis of gliomas .And be sig-nificance to evaluate the biological behavior of glioma, and can provide evidence for instituting reasonable therapy scheme, judgging prognosis and assessing curative effect in clinic.
