CAJ | 학술논문

目的：探讨抗P-选择素（P-selectin）及血小板糖蛋白Ⅱb/Ⅲa（GPⅡb/Ⅲa）抗体测定在鉴别特发性血小板减少性紫癜（ITP）和原发性干燥综合征（pSS）伴血小板减少鉴别诊断中的意义。方法采用ELISA法分别测定40例ITP患者，36例pSS伴血小板减少患者及40名正常人血浆中的抗P-selectin及GPⅡb/Ⅲa抗体。结果 pSS伴血小板减少组、ITP组抗P-selectin及GPⅡb/Ⅲa抗体水平及阳性率均高于正常对照组（P＜0.01）；pSS伴血小板减少组抗P-selectin抗体水平及阳性率显著高于ITP组（P＜0.01）；而pSS伴血小板减少组抗GPⅡb/Ⅲa抗体水平及阳性率与ITP组比较差异无统计学意义（P＞0.05）。结论抗P-selectin及GPⅡb/Ⅲa抗体测定在ITP和pSS伴血小板减少鉴别诊断中有显著的临床意义。
목적：탐토항P-선택소（P-selectin）급혈소판당단백Ⅱb/Ⅲa（GPⅡb/Ⅲa）항체측정재감별특발성혈소판감소성자전（ITP）화원발성간조종합정（pSS）반혈소판감소감별진단중적의의。방법채용ELISA법분별측정40례ITP환자，36례pSS반혈소판감소환자급40명정상인혈장중적항P-selectin급GPⅡb/Ⅲa항체。결과 pSS반혈소판감소조、ITP조항P-selectin급GPⅡb/Ⅲa항체수평급양성솔균고우정상대조조（P＜0.01）；pSS반혈소판감소조항P-selectin항체수평급양성솔현저고우ITP조（P＜0.01）；이pSS반혈소판감소조항GPⅡb/Ⅲa항체수평급양성솔여ITP조비교차이무통계학의의（P＞0.05）。결론항P-selectin급GPⅡb/Ⅲa항체측정재ITP화pSS반혈소판감소감별진단중유현저적림상의의。
Objective To study the clinical signifi cance of determining anti-P-selectin antibodies and anti-platelet glycoproteinⅡb/Ⅲa (GPⅡb/Ⅲa) antibodies in the differential diagnosis of idiopathic thrombocytopenic purpura (ITP) and primary Sj?gren Syndrome (pSS) with thrombocytopenia.Methods Plasma anti-P-selectin antibodies and anti-platelet glycoproteinⅡb/Ⅲa antibodies in 40 patients with ITP, 36 pSS patients with thrombocytopenia and 40 normal individuals were detected by ELISA method.Results The level of anti-P-selectin antibodies and anti-platelet glycoproteinⅡb/Ⅲa antibodies in patients with ITP and pSS with thrombocytopenia was much higher than that in the normal group (P<0.01), the level and positive rate of anti-P-selectin antibodies in pSS patients with thrombocytopenia were much higher than that in ITP (P<0.01). There was no difference of the level and positive rate of anti-platelet glycoproteinⅡb/Ⅲa antibodies between pSS patients with thrombocytopenia and ITP (P>0.05).Conclusion Detecting anti-P-selectin antibodies and anti-platelet glycoproteinⅡb/Ⅲa antibodies might be helpful for differential diagnosis of ITP and pSS patients with thrombocytopenia.