CAJ | 학술논문

目的：：探讨新疆维吾尔族与汉族妇女间miR-146 a ( rs2910164)基因多态性的差异,分析其与宫颈癌发生发展的关系。方法：PCR-RFLP法检测宫颈炎、CIN及宫颈癌组织中 miR-146 a ( rs2910164)基因分型。结果：维吾尔族和汉族间的 miR-146 a (rs2910164)基因型构成比差异显著(χ2=57.927,P<0.001),维吾尔族GG基因型比例显著高于汉族。 Logistic回归分析发现,维吾尔族( OR=3.332,95%CI 1.411~7.868)和肿瘤直径≥4 cm ( OR=3.792,95%CI 1.162~12.376)与miR-146 a ( rs2910164)基因型GG/CG基因型显著相关。结论：新疆维吾尔族与汉组妇女间miR-146 a ( rs2910164)基因多态性差异显著,miR-146a(rs2910164)等位基因G可能参与宫颈癌的病情发展。
목적：：탐토신강유오이족여한족부녀간miR-146 a ( rs2910164)기인다태성적차이,분석기여궁경암발생발전적관계。방법：PCR-RFLP법검측궁경염、CIN급궁경암조직중 miR-146 a ( rs2910164)기인분형。결과：유오이족화한족간적 miR-146 a (rs2910164)기인형구성비차이현저(χ2=57.927,P<0.001),유오이족GG기인형비례현저고우한족。 Logistic회귀분석발현,유오이족( OR=3.332,95%CI 1.411~7.868)화종류직경≥4 cm ( OR=3.792,95%CI 1.162~12.376)여miR-146 a ( rs2910164)기인형GG/CG기인형현저상관。결론：신강유오이족여한조부녀간miR-146 a ( rs2910164)기인다태성차이현저,miR-146a(rs2910164)등위기인G가능삼여궁경암적병정발전。
Objective:To explore the difference between Uyghur and Han women in miR-146a(rs2910164)gene polymorphism and analyze its relationship with occurrence and de-velopment of cervical cancer. Methods:The genotype of miR-146a was detected by RCR-RFLP in tissue of cervicitis, CIN and cervical cancer. Results:The result of PCR-RFLP showed the significant difference between Uyghur and Han in miR-146 a ( rs2910164 ) genotype (χ2 =57. 927,P<0. 001). The proportion of the Uyghur GG genotype was significantly higher than that of the Han nationality. The Logistic regression analysis of miR-146a(rs2910164)genotype and clinical pathological characteristics found that the Uyghur( OR=3. 332,95%CI 1. 411 ~7. 868)and tumor diameter≥4cm(OR=3. 792,95%CI 1. 162~12. 376)were significantly as-sociated with GG/CG genotypes. Conclusion:There is a significant difference between Uygur and Han women in miR-146a(rs2910164) gene polymorphism,miR-146a (rs2910164) G al-lele may be involved in the progression of cervical cancer.