延边医学
延邊醫學
연변의학
YAN BIAN YI XUE
2015年
13期
9-11
,共3页
流感嗜血杆菌%儿童%耐药性
流感嗜血桿菌%兒童%耐藥性
류감기혈간균%인동%내약성
Haemophilus influenza%children%resistance
目的：了解儿童分离流感嗜血杆菌（Hi）的分布及耐药情况，为临床合理使用抗菌药物、预防和控制感染提供依据。方法：收集长沙市中心医院、长沙市第三医院、长沙市第一医院，2013年1月～2014年2月儿童各类临床标本Hi分离株249株，采用梅里埃全自动微生物鉴定仪进行菌种鉴定，纸片扩散法（K- B法）进行药敏试验，头孢硝噻酚试验检测β-内酰胺酶。结果：儿童Hi以冬季和春季分离率较高，为38.15％、29.32％,以1-3岁儿童分离率最高，占总数的51.8%。Hi 噁对氨苄西林、复方磺胺甲唑、头孢呋辛的耐药率较高，依次为81.12%、63.45%、38.96%，对氨苄西林/舒巴坦、头孢曲松、头孢噻肟、环丙沙星、氧氟沙星、洛美沙星、左氧氟沙星、四环素的敏感率均高于70%。结论：Hi 噁对氨苄西林和复方磺胺甲唑耐药严重，而β-内酰胺酶抑制剂、第2、3代头孢类药物、阿奇霉素可作为优先选择药物。
目的：瞭解兒童分離流感嗜血桿菌（Hi）的分佈及耐藥情況，為臨床閤理使用抗菌藥物、預防和控製感染提供依據。方法：收集長沙市中心醫院、長沙市第三醫院、長沙市第一醫院，2013年1月～2014年2月兒童各類臨床標本Hi分離株249株，採用梅裏埃全自動微生物鑒定儀進行菌種鑒定，紙片擴散法（K- B法）進行藥敏試驗，頭孢硝噻酚試驗檢測β-內酰胺酶。結果：兒童Hi以鼕季和春季分離率較高，為38.15％、29.32％,以1-3歲兒童分離率最高，佔總數的51.8%。Hi 噁對氨芐西林、複方磺胺甲唑、頭孢呋辛的耐藥率較高，依次為81.12%、63.45%、38.96%，對氨芐西林/舒巴坦、頭孢麯鬆、頭孢噻肟、環丙沙星、氧氟沙星、洛美沙星、左氧氟沙星、四環素的敏感率均高于70%。結論：Hi 噁對氨芐西林和複方磺胺甲唑耐藥嚴重，而β-內酰胺酶抑製劑、第2、3代頭孢類藥物、阿奇黴素可作為優先選擇藥物。
목적：료해인동분리류감기혈간균（Hi）적분포급내약정황，위림상합리사용항균약물、예방화공제감염제공의거。방법：수집장사시중심의원、장사시제삼의원、장사시제일의원，2013년1월～2014년2월인동각류림상표본Hi분리주249주，채용매리애전자동미생물감정의진행균충감정，지편확산법（K- B법）진행약민시험，두포초새분시험검측β-내선알매。결과：인동Hi이동계화춘계분리솔교고，위38.15％、29.32％,이1-3세인동분리솔최고，점총수적51.8%。Hi 오대안변서림、복방광알갑서、두포부신적내약솔교고，의차위81.12%、63.45%、38.96%，대안변서림/서파탄、두포곡송、두포새우、배병사성、양불사성、락미사성、좌양불사성、사배소적민감솔균고우70%。결론：Hi 오대안변서림화복방광알갑서내약엄중，이β-내선알매억제제、제2、3대두포류약물、아기매소가작위우선선택약물。
Objective To investigate the prevalence and antibiotic resistance of Haemophilus influenza in children, and provide a guidline for prevention , clinical diagnosis and rational use of antibiotics. Methods 249 strains of Haemophilus influenza from various clinical specimens were col ected from the Third hospital of Changsha , the First hospital of Changsha and Changsha Central Hospital from Jan 2013 to Feb 2014.Al of them were identified by VITEK 2 com-pact .The antimicrobial susceptibility testing was performed by Kirby- Bauer disc diffusion method,and the nitrocefin phenol test was performed byβ- lacta-mase test. Results Results The isolation rate of Haemophilus influenza in winter and in spring was higher,were 38.15%and 29.32%.there was a high influenza rate in children from 1 to 3 years old. Haemophilus influenza was resistant to ampicil in ,compound sulfamethoxazole and cefuroxime, were81.12%,63.45%and 38.96% , while was sensitive to ampicil in/sulbactam,cefatriaxone,cefotaxime,ciprofloxacin,lomefloxacin,ofloxacin,evofloxacin,tetracycline. Conclutions Haemophilus influenza is resistant to ampicil in and compound sulfamethoxazole,while making it a priority to beta- lactamase inhibitor ,cephalosporins and azithromycin.
