实用癌症杂志
實用癌癥雜誌
실용암증잡지
THE PRACTICAL JOURNAL OF CANCER
2015年
4期
491-493,496
,共4页
姜艳辉%曲红梅%孙伟%朱新冰%刘东
薑豔輝%麯紅梅%孫偉%硃新冰%劉東
강염휘%곡홍매%손위%주신빙%류동
腹腔镜%结直肠癌%免疫功能%炎症反应
腹腔鏡%結直腸癌%免疫功能%炎癥反應
복강경%결직장암%면역공능%염증반응
Laparoscopic%Colorectal cancer%Immune function%Inflammation
目的:探讨腹腔镜和开腹结直肠癌根治术对患者的机体炎症免疫反应的影响。方法选取45例结直肠癌患者随机分为两组:腹腔镜组和对照组,腹腔镜组23例,在腹腔镜下行结直肠癌根治术;对照组患者22例,采用传统开腹结直肠癌根治术。分别于术前及术后第1 d,术后第7 d测定IgA、IgM、IgG、CD3+、CD4+、CD8+、NK细胞活性、IL-6、IL-10、TNF–á及CRP,并进行对比。结果术后第3 d时,与术前相比两组患者的CD3+、CD8+、IgA、IgM、IgG水平均出现降低,CRP浓度、TNF–á和IL-6水平出现上升;术后第7 d,腹腔镜组比对照组患者的CD3+与CD4+水平降低更加显著,而NK细胞活性无明显变化。术后第3 d腹腔镜组IgM水平明显高于对照组;术后第3 d和第7 d,腹腔镜组CRP浓度显著低于对照组,腹腔镜组IL-6水平明显低于对照组,此外术后第7 d时腹腔镜组TNF–á浓度恢复至术前水平,腹腔镜组患者术后的IL-10水平显著高于对照组。结论与传统的开腹手术相比,于腹腔镜下进行结直肠癌根治术对于患者的机体的免疫系统的影响相对更小,并且炎症反应更轻。
目的:探討腹腔鏡和開腹結直腸癌根治術對患者的機體炎癥免疫反應的影響。方法選取45例結直腸癌患者隨機分為兩組:腹腔鏡組和對照組,腹腔鏡組23例,在腹腔鏡下行結直腸癌根治術;對照組患者22例,採用傳統開腹結直腸癌根治術。分彆于術前及術後第1 d,術後第7 d測定IgA、IgM、IgG、CD3+、CD4+、CD8+、NK細胞活性、IL-6、IL-10、TNF–á及CRP,併進行對比。結果術後第3 d時,與術前相比兩組患者的CD3+、CD8+、IgA、IgM、IgG水平均齣現降低,CRP濃度、TNF–á和IL-6水平齣現上升;術後第7 d,腹腔鏡組比對照組患者的CD3+與CD4+水平降低更加顯著,而NK細胞活性無明顯變化。術後第3 d腹腔鏡組IgM水平明顯高于對照組;術後第3 d和第7 d,腹腔鏡組CRP濃度顯著低于對照組,腹腔鏡組IL-6水平明顯低于對照組,此外術後第7 d時腹腔鏡組TNF–á濃度恢複至術前水平,腹腔鏡組患者術後的IL-10水平顯著高于對照組。結論與傳統的開腹手術相比,于腹腔鏡下進行結直腸癌根治術對于患者的機體的免疫繫統的影響相對更小,併且炎癥反應更輕。
목적:탐토복강경화개복결직장암근치술대환자적궤체염증면역반응적영향。방법선취45례결직장암환자수궤분위량조:복강경조화대조조,복강경조23례,재복강경하행결직장암근치술;대조조환자22례,채용전통개복결직장암근치술。분별우술전급술후제1 d,술후제7 d측정IgA、IgM、IgG、CD3+、CD4+、CD8+、NK세포활성、IL-6、IL-10、TNF–á급CRP,병진행대비。결과술후제3 d시,여술전상비량조환자적CD3+、CD8+、IgA、IgM、IgG수평균출현강저,CRP농도、TNF–á화IL-6수평출현상승;술후제7 d,복강경조비대조조환자적CD3+여CD4+수평강저경가현저,이NK세포활성무명현변화。술후제3 d복강경조IgM수평명현고우대조조;술후제3 d화제7 d,복강경조CRP농도현저저우대조조,복강경조IL-6수평명현저우대조조,차외술후제7 d시복강경조TNF–á농도회복지술전수평,복강경조환자술후적IL-10수평현저고우대조조。결론여전통적개복수술상비,우복강경하진행결직장암근치술대우환자적궤체적면역계통적영향상대경소,병차염증반응경경。
Objective To investigate the influence of laparoscopic and open radical resection of colorectal cancer on im-muno-inflammatory reactions.Methods 45 cases of colorectal cancer patients were randomly divided into 2 groups.The laparo-scopic group ( 23 cases )received laparoscopic resection of colorectal cancer;the control group (22 cases) received traditional open resection of colorectal cancer.IgA,IgM,IgG,CD3 +,CD4 +,CD8 +,NK cell activity,IL-6,IL-10,TNF–á and CRP were detected and compared 1d before and after the surgery,and 7 d after the surgery.Results 3 d after the surgery,CD3 +,CD8 +, IgA,IgM,IgG decreased in both groups,CRP concentration,TNF,and IL-6-level increased;7 d after operation,CD3 +and CD4 +levels in the laparoscopic group decreased more significantly than those of the control group,and the activity of NK cells had no obvious change.3 d after operation,IgM level in the laparoscopic group was significantly higher than that of the control group;3 d and 7 d after operation, the concentration of CRP in the laparoscopic group were significantly lower than those of the control group,the level of IL-6 in the laparoscopic group was significantly lower than that of the control group,7 d after operation,the con-centration of TNF–á in the laparoscopic group recovered to the preoperative level,postoperative IL-10 level was significantly higher than that of the control group.Conclusion Compared with traditional open operation,laparoscopic resection of colorectal cancer has smaller effect on immune function with lighter inflammatory reactions.