CAJ | 학술논문

目的：探讨充分血液透析的慢性肾脏病（CKD）5期患者左心室肥厚（LVH）的发生情况及相关危险因素。方法应用超声心动图测量106例CKD 5期患者室间隔厚度（IVST）、左心室后壁厚度（LVPWT）、左心室射血分数（LVEF）。结果（1）106例 CKD 5期患者中，共有94例发生LVH，总发生率为88.68%。50例（100.00%）糖尿病肾病组（DKD）患者均发生LVH，而56例非糖尿病肾病组（NDKD）患者中也有44例（78.57%）发生LVH。（2）与NLVH组患者相比，LVH组年龄较大（P=0.003）、60岁以上患者较多（P=0.046）、糖尿病患者较多（P=0.013）。（3）多元线性回归分析提示C反应蛋白（CRP）（P＜0.001）、BMI（P=0.001）及年龄（P=0.030）是IVST的危险因素，CRP（P＜0.001）、BMI（P=0.016）、年龄（P=0.006）、舒张压（diastolic pressure，DBP）（P=0.033）是LVPET的危险因素。结论充分透析的CKD 5期患者中存在较高的LVH发生率。DKD组患者较NDKD组更易发生LVH。增龄、BMI较高、微炎症状态及舒张压升高是本组CKD 5期患者发生LVH的危险因素。
목적：탐토충분혈액투석적만성신장병（CKD）5기환자좌심실비후（LVH）적발생정황급상관위험인소。방법응용초성심동도측량106례CKD 5기환자실간격후도（IVST）、좌심실후벽후도（LVPWT）、좌심실사혈분수（LVEF）。결과（1）106례 CKD 5기환자중，공유94례발생LVH，총발생솔위88.68%。50례（100.00%）당뇨병신병조（DKD）환자균발생LVH，이56례비당뇨병신병조（NDKD）환자중야유44례（78.57%）발생LVH。（2）여NLVH조환자상비，LVH조년령교대（P=0.003）、60세이상환자교다（P=0.046）、당뇨병환자교다（P=0.013）。（3）다원선성회귀분석제시C반응단백（CRP）（P＜0.001）、BMI（P=0.001）급년령（P=0.030）시IVST적위험인소，CRP（P＜0.001）、BMI（P=0.016）、년령（P=0.006）、서장압（diastolic pressure，DBP）（P=0.033）시LVPET적위험인소。결론충분투석적CKD 5기환자중존재교고적LVH발생솔。DKD조환자교NDKD조경역발생LVH。증령、BMI교고、미염증상태급서장압승고시본조CKD 5기환자발생LVH적위험인소。
Objective To investigate the incidence of left ventricular hypertrophy (LVH) in adequate hemodialysis patients with chronic kidney disease (CKD) at stage 5 period and its related risk factors. Methods A total of adequate hemodialysis 106 patients with CKD at stage 5 period were analysis. Ultrasonic cardiogram was performed to measure interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT) and left ventricular ejection fraction (LVEF). Results (1) In 106 patients with CKD 5 period, a total of 94 cases of LVH, the total incidence was 88.68%. 50 cases (100.00%) of diabetic kidney diseases (DKD) group patients had occurred LVH incidence, and 56 cases of non-diabetic kidney diseases (NDKD) group has 44 cases (78.57%) in patients with LVH. (2) The age (P=0.003), more than 60 years of age (P=0.046), number of patients with DKD (P=0.013) were significantly higher in LVH group than in NLVH group. (3) Multiple linear regression analysis showed that C-reactive protein (CRP) (P<0.001), BMI (P=0.001) and age (P=0.030) were the risk factors related to IVST;CRP (P<0.001), BMI (P=0.016), age (P=0.006), diastolic pressure (DBP) (P=0.033) were the risk factors related to LVPET. Conclusion The incidence of LVH are high among patients in adequate hemodialysis patients with CKD at stage 5 period. The incidence of patients with LVH was higher in DKD group than in NDKD group. Age, BMI, slightly inflammatory state and DBP might be the risk factors related to LVH.