CAJ | 학술논문

目的：探讨更昔洛韦联合炎琥宁治疗带状疱疹病毒性角膜炎的临床疗效。方法：选取83例带状疱疹病毒性角膜炎患者，随机分为观察组（n=38）和对照组（n=45），对照组仅给予更昔洛韦胶囊，观察组采用更昔洛韦胶囊联合炎琥宁，比较两组患者临床疗效、症状变化及外周血细胞因子。结果：对照组和观察组治疗总有效率分别为73.3%、92.1%，观察组疗效明显优于对照组（P<0.05）。治疗后，观察组眼干涩不适消失时间、疼痛及畏光缓解时间、角膜损伤愈合时间、荧光素染色转阴时间等均显著短于对照组（P<0.05）。观察组患者血清IL-2、IFN-γ显著升高，IL-4、IL-10显著降低，与对照组比较差异具有统计学意义（P<0.05）。结论：采用更昔洛韦胶囊联合炎琥宁治疗带状疱疹病毒性角膜炎安全有效，值得临床推广使用。
목적：탐토경석락위연합염호저치료대상포진병독성각막염적림상료효。방법：선취83례대상포진병독성각막염환자，수궤분위관찰조（n=38）화대조조（n=45），대조조부급여경석락위효낭，관찰조채용경석락위효낭연합염호저，비교량조환자림상료효、증상변화급외주혈세포인자。결과：대조조화관찰조치료총유효솔분별위73.3%、92.1%，관찰조료효명현우우대조조（P<0.05）。치료후，관찰조안간삽불괄소실시간、동통급외광완해시간、각막손상유합시간、형광소염색전음시간등균현저단우대조조（P<0.05）。관찰조환자혈청IL-2、IFN-γ현저승고，IL-4、IL-10현저강저，여대조조비교차이구유통계학의의（P<0.05）。결론：채용경석락위효낭연합염호저치료대상포진병독성각막염안전유효，치득림상추엄사용。
Objective: To evaluate the effect of ganciclovir capsules combined with Yanhuning treatment on patients with herpes zoster keratitis. Methods: The 83 patients with herpes zoster keratitis were divided into observation group (n=38) and control group (n=45). Ganciclovir capsules combined with Yanhuning were used in the observation group and ganciclovir capsules alone were used in the control group. The clinical curative effect, clinical symptoms and the change of peripheral blood cytokines were compared be-tween the two groups. Results: The efficiency of clinical treatment was 92.1% in the observation group, as compared with that of 73.3% in the control group (P<0.05). After treatment, the symptom improve times of dry discomfort disappear, photophobia and pain relieving, corneal injury healing and fluorescein staining turn negative in the observation group were significantly shorter than those in the control group (P<0.05). In the observation group, the serum IL-2 and IFN-γ significantly increased, meanwhile IL-4, IL-10 signif-icantly reduced (P<0.05). Conclusion: Using ganciclovir capsules combined with Yanhuning treatment in patients with herpes zoster keratitis is safe and effective, worth clinical promotion.