药学与临床研究
藥學與臨床研究
약학여림상연구
PHARMACEUTICAL AND CLINICAL RESEARCH
2015年
2期
191-193
,共3页
严定强%朱怀军%彭婕%童静婷
嚴定彊%硃懷軍%彭婕%童靜婷
엄정강%주부군%팽첩%동정정
地佐辛%不良反应%分析
地佐辛%不良反應%分析
지좌신%불량반응%분석
Dezocine%Adverse Reactions%Analysis
目的：评价地佐辛不良反应发生相关风险因素，为临床合理用药提供参考信息。方法：通过我院HIS收集2013年地佐辛注射液使用情况，通过国家药品不良反应监测系统收集其不良反应发生情况并对所有使用患者核实以排除不良反应漏报情况；对年龄、性别等因素采用单因素和多因素Logistic回归，逐步向前法筛选变量。结果：2013年我院地佐辛注射液使用患者3257例，发生不良反应者56例。单因素和多因素Logistic回归分析均显示具有统计学意义（P<0.05）的影响因素为：性别、肝病、科室。结论：地佐辛不良反应的发生可能与性别、肝病和科室有关。
目的：評價地佐辛不良反應髮生相關風險因素，為臨床閤理用藥提供參攷信息。方法：通過我院HIS收集2013年地佐辛註射液使用情況，通過國傢藥品不良反應鑑測繫統收集其不良反應髮生情況併對所有使用患者覈實以排除不良反應漏報情況；對年齡、性彆等因素採用單因素和多因素Logistic迴歸，逐步嚮前法篩選變量。結果：2013年我院地佐辛註射液使用患者3257例，髮生不良反應者56例。單因素和多因素Logistic迴歸分析均顯示具有統計學意義（P<0.05）的影響因素為：性彆、肝病、科室。結論：地佐辛不良反應的髮生可能與性彆、肝病和科室有關。
목적：평개지좌신불량반응발생상관풍험인소，위림상합리용약제공삼고신식。방법：통과아원HIS수집2013년지좌신주사액사용정황，통과국가약품불량반응감측계통수집기불량반응발생정황병대소유사용환자핵실이배제불량반응루보정황；대년령、성별등인소채용단인소화다인소Logistic회귀，축보향전법사선변량。결과：2013년아원지좌신주사액사용환자3257례，발생불량반응자56례。단인소화다인소Logistic회귀분석균현시구유통계학의의（P<0.05）적영향인소위：성별、간병、과실。결론：지좌신불량반응적발생가능여성별、간병화과실유관。
Objective: To assess the risk factors of dezocine in order to provide reference information for the clinical rational use. Methods: Data were collected for the utilization of dezocine in 2013 through HIS; the occurrence of adverse reactions were collected through the national information system of monitoring adverse reaction and verified. The data collected were treated with univariate and multivariate analysis of variance, forward stepwise selection of variables. Results: Dezocine was used in 3257 patients in 2013, adverse reactions occurred in 56 cases. The result of univariate and multivariate analysis of variance showed that sex, departments and liver disease were the main risk factors (P<0.05). Conclusion:Adverse effects of dezocine may be associated with sex, liver disease and the department.
