CAJ | 학술논문

目的：探讨维生素 B1与帕罗西汀联合治疗卒中后抑郁症（PSD）的临床疗效。方法：PSD 患者60例随机分为联合组和对照组各30例。2组均给予帕罗西汀治疗，联合组在此基础上给予维生素 B1治疗，疗程8周。于治疗前及治疗开始后2、4、8周时分别使用汉密尔顿抑郁量表（HAMD）、抑郁自评量表（SDS）评估疗效，采用不良反应量表（TESS）评估不良反应。结果：2组治疗第2周末疗效差异无统计学意义（P>0.05）；第4、8周末联合组的 HAMD、SDS 评分较对照组下降（P<0.05），疗效优于对照组（P<0.05）。 TESS 评分差异无统计学意义（P>0.05）。结论：维生素 B1联合帕罗西汀治疗 PSD 较单用帕罗西汀疗效显著，且不会增加不良反应。
목적：탐토유생소 B1여파라서정연합치료졸중후억욱증（PSD）적림상료효。방법：PSD 환자60례수궤분위연합조화대조조각30례。2조균급여파라서정치료，연합조재차기출상급여유생소 B1치료，료정8주。우치료전급치료개시후2、4、8주시분별사용한밀이돈억욱량표（HAMD）、억욱자평량표（SDS）평고료효，채용불량반응량표（TESS）평고불량반응。결과：2조치료제2주말료효차이무통계학의의（P>0.05）；제4、8주말연합조적 HAMD、SDS 평분교대조조하강（P<0.05），료효우우대조조（P<0.05）。 TESS 평분차이무통계학의의（P>0.05）。결론：유생소 B1연합파라서정치료 PSD 교단용파라서정료효현저，차불회증가불량반응。
Objective: To explore the clinical effect of combination of vitamin B1 and paroxeting in the treatment of post-stroke depression (PSD). Methods: Sixty PSD patients were randomly divided into combination group and control group, with 30 cases in each group. Both the groups were given paroxiting, and the combination group was given additional vitamin B1 for 8 weeks. The clinical effect was measured by Hamilton Depression Scale (HAMD) and Self-rating Depression Scale (SDS) before the treatment and at the ends of 2nd, 4th, 8th week of the treatment. Moreover, the treatment emergent symptom scale (TESS) was used to observe the side effects. Results: At the end of the 2nd week, there was no significantly difference in the clinical effect in the two groups (P>0.05). At the end of 4th and 8th week treatment, scores of the HAMD and SDS were decreased more significantly in the combination group than those in the control group (P<0.05), and the clinical effect was better in the combination group (P<0.05). There was no significantly difference in the TESS scores in the 2 groups (P>0.05). Conclusion: Paroxeting com-bined with vitamin B1 shows better clinical efficacy than single paroxeting in the treatment of PSD.